Brain Connectivity Pattern Changes Associated With Psychedelic-Assisted Psychotherapy
Prince Patel, Samrat Gollapudi, Brian Joseph Mathew, Bhaumik B. Patel
May 2, 2024 DOI: 10.31986/issn.2689-0690_rdw.stratford_research_day.179_2024 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Systematic review |
|---|---|
| Topics | Psychedelic-assisted therapy |
| Keywords | Psychotherapist |
| Key findings | Psychedelics induce acute network disintegration and desegregation in the brain, and post-acute effects include increased default mode network integrity and connectivity. |
Abstract
Psychedelic-assisted psychotherapy (PAP) has shown promising therapeutic benefits for various psychiatric disorders, but the underlying neural mechanisms remain unclear. This study aimed to investigate the effects of psychedelics on brain connectivity patterns using functional magnetic resonance imaging (fMRI). A comprehensive literature search was conducted in PubMed and Google Scholar databases using relevant keywords related to psychedelics, connectivity, therapy, and fMRI. Only studies involving major psychedelic compounds (LSD, psilocybin, ayahuasca) and measuring outcomes via fMRI were included. The findings from the reviewed studies suggest that psychedelics induce acute disruptions in normal large-scale brain network patterns, leading to a compromised modular but enhanced global connectivity, referred to as network "disintegration" and "desegregation." This "internal" brain state correlates with aspects of the psychedelic experience, such as ego dissolution. Post-acute effects, one day after psilocybin treatment, revealed changes in cerebral blood flow and resting-state functional connectivity compared to baseline, including increased default mode network (DMN) integrity and functional connectivity within the DMN. The proposed therapeutic mechanisms of PAP involve the synergistic combination of the psychedelic substance and the accompanying psychotherapy. Further research is warranted to delineate the specific brain connectivity changes associated with different psychedelic compounds and their relationship to therapeutic outcomes in various psychiatric conditions.
Comparable studies
Other systematic reviews and meta-analyses on psychedelic-assisted therapy, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| A Meta-Analysis of Placebo-Controlled Trials of Psychedelic-Assisted Therapy | 2020 | Systematic review | |
| Psychedelic-Assisted Psychotherapy—A Systematic Review of Associated Psychological Interventions | 2022 | Systematic review | |
| Psychedelic therapy for depressive symptoms: A systematic review and meta-analysis. Participants in studies of psychedelic therapy for depressive symptoms (Major... | 2023 | Systematic review with meta-analysis | n = 14 |
| Psilocybin-assisted therapy for depression: A systematic review and meta-analysis. Patients diagnosed with life-threatening illnesses or major depressive disorder | 2023 | Systematic review and meta-analysis | n = 686 |
| Treating posttraumatic stress disorder with MDMA-assisted psychotherapy: A preliminary meta-analysis and comparison to prolonged exposure therapy Patients with PTSD | 2016 | Meta-analysis |