Which Psychotherapy Model Should be Used in Psilocybin Treatment for Depression?
Elena Koning, Pedro Starzynski Bacchi, Cristiano Chaves, Fabiano A. Gomes, Elisa Brietzke
Trends in Psychiatry and Psychotherapy 2025 DOI: 10.47626/2237-6089-2025-1197 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Psilocybin Depression |
| Keywords | Psychological intervention Relevance law Depression economics Psychological therapy Psychotherapist Clinical psychology Work physics Medline |
| Key findings | Both models of psychological intervention in psilocybin-assisted therapy may have clinical relevance for depression treatment. |
Abstract
Although each PAP model differs, both may have clinical relevance in depression treatment. Future work should explore the standardized reporting of psychological interventions in PAP and comparative study designs to better evaluate non-specific and specific models and inform treatment guidelines.
Comparable studies
Other narrative reviews on psilocybin for depression, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function. General population | 2019 | Integrative review | |
| Molecular Mechanisms of Psilocybin and Implications for the Treatment of Depression | 2021 | Review | |
| Registered clinical studies investigating psychedelic drugs for psychiatric disorders. Registered clinical trials on clinicaltrials.gov evaluating psychedelics for... | 2021 | Review | n = 70 |
| Depression, Mindfulness, and Psilocybin: Possible Complementary Effects of Mindfulness Meditation and Psilocybin in the Treatment of Depression. A Review | 2020 | Review | |
| From psychiatry to neurology: Psychedelics as prospective therapeutics for neurodegenerative disorders | 2021 | Review |