Recommendations and Consensus Statements on Psilocybin-Assisted Psychotherapy (PAP) for Depression: A Rapid Review and Thematic Analysis
Aimee Freeburn, Alene Sze Jing Yong, Simon Bell
Open Science Framework 2025 DOI: 10.17605/osf.io/gzvb3 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Systematic review Peer reviewed |
|---|---|
| Population | Adults living with depression |
| Intervention | Psilocybin-assisted psychotherapy |
| Topics | Depression Psilocybin Psychedelic-assisted therapy |
| Keywords | Thematic analysis Psychotherapist Medline Position paper |
| Key findings | International clinical guidelines and position statements recommend psilocybin-assisted psychotherapy for depression but differ in specific implementation recommendations. |
Abstract
This rapid review aims to synthesise recommendations and statements from international clinical guidelines, consensus statements, and position statements regarding the medical use of psilocybin-assisted psychotherapy (PAP) in adults living with depression.
Comparable studies
Other systematic reviews and meta-analyses on psilocybin and psychedelic-assisted therapy, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| A Meta-Analysis of Placebo-Controlled Trials of Psychedelic-Assisted Therapy | 2020 | Systematic review | |
| Psychedelic therapy for depressive symptoms: A systematic review and meta-analysis. Participants in studies of psychedelic therapy for depressive symptoms (Major... | 2023 | Systematic review with meta-analysis | n = 14 |
| Psilocybin-assisted therapy for depression: A systematic review and meta-analysis. Patients diagnosed with life-threatening illnesses or major depressive disorder | 2023 | Systematic review and meta-analysis | n = 686 |
| United States National Institutes of Health grant funding for psychedelic-assisted therapy clinical trials from 2006-2020. | 2022 | Systematic review | |
| Safety and risk assessment of psychedelic psychotherapy: A meta-analysis and systematic review. Human subjects in studies of psychedelic-assisted psychotherapy | 2024 | Systematic review and meta-analysis | n = 30 |