Acute Effects of Psilocybin and Salvinorin-A on Functional Connectivity
Frederick A. Bagdasarian, Hanne D. Hansen, Chi‐hyeon Yoo, Michael S. Placzek, Jacob M Hooker, Hsiao‐ying Wey
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition August 14, 2024 DOI: 10.58530/2023/3494 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Population | Non-human primates |
| Interventions | Psilocybin Salvinorin-A |
| Topics | Default mode network Psilocybin Serotonin Salvia divinorum |
| Keywords | Hallucinogen Claustrum Κ-opioid receptor Agonist Functional connectivity |
| Key findings | Psilocybin and Salvinorin-A produce overlapping and differing effects on functional connectivity within the default mode network and claustrum. |
Abstract
This work utilized fMRI to assess the influence of the psychedelics, Psilocybin, a serotonergic agonist, and Salvinorin-A, a kappa-opioid receptor (KOR) agonist, on functional connectivity (FC) in non-human primates. We used a seed-based FC analysis, probing regions of interest associated with psychedelic hallucinogens. Our findings highlight the overlapping and differing influence of these substances on FC relative to the subcomponents of the default mode network and the claustrum. This work may provide insight on the mechanisms of action of psychedelics that target differing receptor systems. Key Words: Functional connectivity; Claustrum; DMN; Psychedelics.
Comparable studies
Other preclinical and animal studies on salvia divinorum, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Effects of the plant-derived hallucinogen salvinorin A on basal dopamine levels in the caudate putamen and in a conditioned place aversion assay in mice: agonist actions at kappa opioid receptors. Mice | 2005 | Experimental study | |
| Potential anxiolytic‐ and antidepressant‐like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodents Male Sprague-Dawley rats and male Albino Swiss mice | 2009 | Experimental study | |
| Involvement of kappa-opioid and endocannabinoid system on Salvinorin A-induced reward. Wistar rats | 2008 | Experimental study | |
| Role of kappa-opioid receptors in the effects of salvinorin A and ketamine on attention in rats. Rats | 2010 | Experimental study | |
| The plant-derived hallucinogen, salvinorin A, produces kappa-opioid agonist-like discriminative effects in rhesus monkeys. Rhesus monkeys | 2004 | Experimental study | n = 3 |