Does psilocybin help with mental health conditions?
Zenodo (CERN European Organization for Nuclear Research) January 22, 2026 DOI: 10.5281/zenodo.18339283 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review/statement Peer reviewed |
|---|---|
| Population | Mental health conditions (depression, substance use disorders) |
| Intervention | Psilocybin therapy |
| Topics | Depression Psilocybin |
| Keywords | Depression economics Substance use Mental health care Hallucinogen Psychotherapist |
| Key findings | Psilocybin therapy shows potential benefits for depression and substance use disorders, though long-term safety and efficacy require further study. |
Abstract
Psilocybin therapy shows potential benefits for mental health conditions such as depression and substance use disorders, though further research is needed to confirm long-term safety and efficacy.
Comparable studies
Other narrative reviews on psilocybin for depression, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function. General population | 2019 | Integrative review | |
| Molecular Mechanisms of Psilocybin and Implications for the Treatment of Depression | 2021 | Review | |
| Registered clinical studies investigating psychedelic drugs for psychiatric disorders. Registered clinical trials on clinicaltrials.gov evaluating psychedelics for... | 2021 | Review | n = 70 |
| Depression, Mindfulness, and Psilocybin: Possible Complementary Effects of Mindfulness Meditation and Psilocybin in the Treatment of Depression. A Review | 2020 | Review | |
| From psychiatry to neurology: Psychedelics as prospective therapeutics for neurodegenerative disorders | 2021 | Review |