Overview Of Review (OoR) on PSILOCYBIN in Psychiatric Disorders
Pierfelice Cutrufelli, Antonio Di Francesco, Alessandro Rodolico, Carmen Concerto, Rosaria Furnari, Leonardo Marano, Ludovico Mineo, Alessandro Moncada, Martina Rampello, Antonino Petralia, Maria Salvina Signorelli
August 4, 2024 DOI: 10.37766/inplasy2024.8.0022 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Protocol for an overview of reviews Randomized |
|---|---|
| Population | Patients included in systematic reviews who have undergone psilocybin therapy for various clinical indications (DSM-5-TR or ICD-10 disorders) |
| Intervention | Psilocybin therapy |
| Topics | Psilocybin |
| Keywords | Hallucinogen |
| Key findings | This is a protocol and does not report findings; the planned overview aims to consolidate evidence on psilocybin therapy's efficacy, safety, and adverse effects. |
Abstract
eview question / Objective This protocol outlines the methodology for an "Overview of Review" (OoR) study which aims to conduct a comprehensive analysis of systematic reviews with meta-analyses of psilocybin randomized clinical trials.The primary objective is to provide an evaluation of the therapeutic effects, safety profiles, and adverse effects of psilocybin as documented in the best evidence available.: P (Population): Patients included in systematic reviews who have undergone psilocybin therapy for various clinical indications (DSM-5-TR or ICD-10 Disorders) **I (Intervention)**: Psilocybin therapy.C (Comparison): placebo, no treatment, or other standard drug or no drug therapies O (Outcomes): 1. Therapeutic effects of psilocybin (efficacy).2. Acceptability and tolerability of psilocybin therapy 3. Prevalence and severity of adverse effects associated with psilocybin therapy (safety profile). RationaleThe motivation for this study arises from the recent surge in interest in psilocybin therapy and the need to consolidate the growing body of findings, which at the moment constitute scattered evidence.Psilocybin, a naturally occurring psychedelic compound found in certain species of mushrooms, has garnered significant scientific and therapeutic interest in recent years.Given the p o t e n t i a l s i g n i fi c a n c e o f p s i l o c y b i n i n revolutionizing mental health treatment and our understanding of consciousness, along with the rapidly evolving research landscape, this overview of reviews is timely and crucial.It aims to provide a comprehensive, evidence-based assessment of the current state of psilocybin research, which could inform future clinical applications, research directions, and policy decisions.Condition being studied Psilocybin therapy in subjects diagnosed with psychiatric disorders according to international diagnostic criteria such as the ICD-10 and DSM-5-TR.