Historical Perspectives and Pharmacodynamic Actions of the Magic Mushroom (Psilocybin) for Future Global Healthcare
Bennett Lange, Luke Morgan, Christopher Mattox, Suhrud Pathak, Keyi Liu, Rishi M. Nadar, Jun Ren, Jeyaram Bharathi Jeyabalan, Timothy R. Moore, Muralikrishnan Dhanasekaran
Trends in Medical Research June 28, 2024 DOI: 10.3923/tmr.2024.245.273 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Psilocybin |
| Keywords | Pharmacodynamics Health care Magic telescope Mushroom Pharmacology Traditional medicine Hallucinogen Economic growth |
| Key findings | Psilocybin exerts changes in many organ systems through conversion to psilocin, a 5-HT2A agonist. |
Abstract
Many medicines and treatments for varying levels of ailments were found through natural bioactives before complex separation techniques were available.Ironically, as medicine advances, drastically more people seem to be reverting to a desire for these natural bioactives.Due to this, it is important to discover and research the pharmacology of historically used plants and how exactly they can exert their effects.Magic mushrooms are a polyphyletic group of mushrooms that are characterized by the presence of a psychedelic compound (a drug classification that changes mental state and elicits hallucinations), Psilocybin.The PubMed (NIH) database was manually searched for published manuscripts up through the second week of April, 2024 for the current study using an advanced search feature.The keywords used for the search are given below.The search was done using the CDC, NIH and WHO databases.Journal articles, books and book chapters were manually searched under all languages without filter restrictions.Psilocybin has been found to exert a change in many different organ systems of the human body, including the central nervous system, ophthalmic system, cardiovascular system, respiratory system, digestive system, excretory system, endocrine system, immune system, integumentary system, auditory system, smooth muscles, skeletal muscles and spinal cord.This is possible through converting Psilocybin to Psilocin in the liver, which is a 5-HT2A agonist.This review profoundly analyzes magic mushrooms historical, current and future uses as they pertain to the human healthcare system.These uses contain nutraceutical, prophylactic and therapeutic pathways.It will also cover the toxicological effects on these organ systems and how dangerous these effects are.
Comparable studies
Other narrative reviews on psilocybin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function. General population | 2019 | Integrative review | |
| The pharmacology of psilocybin | 2002 | Review | |
| Serotonin research: contributions to understanding psychoses | 2008 | Review | |
| Psychedelics, Meditation, and Self-Consciousness | 2018 | Review | |
| The abuse potential of medical psilocybin according to the 8 factors of the Controlled Substances Act | 2018 | Review |
Citations in the library
Cites 52
- Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial Journal of Psychopharmacology November 30, 2016
- Human hallucinogen research: guidelines for safety. Journal of Psychopharmacology July 1, 2008
- Safety, Tolerability, and Efficacy of Psilocybin in 9 Patients With Obsessive-Compulsive Disorder The Journal of Clinical Psychiatry November 15, 2006
- Acute, subacute and long-term subjective effects of psilocybin in healthy humans: a pooled analysis of experimental studies Journal of Psychopharmacology September 20, 2010
- Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors Science February 16, 2023
and 47 more in the library