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Psilocybin-assisted psychotherapy for depression and anxiety associated with life threatening illness: A phase 2b randomized controlled trial

Margaret Ross, Ravi Iyer, M.l. Williams, Mark Boughey, Clare O’callaghan, Richard Hiscock, Justin Dwyer

General Hospital Psychiatry August 12, 2025 DOI: 10.1016/j.genhosppsych.2025.08.001 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Randomized controlled trial Peer reviewed
Population Individuals with a life-threatening illness
Intervention Psilocybin-assisted psychotherapy
Topics Anxiety Psilocybin Depression Psychedelic-assisted therapy
Keywords Randomized controlled trial Psychotherapist Depression economics Clinical psychology Hallucinogen
Citations 13
Key findings Psilocybin-assisted psychotherapy appears safe and may offer durable relief from depression and anxiety in individuals with a life-threatening illness.

Abstract

Psilocybin-assisted psychotherapy appears safe and may offer durable relief from depression and anxiety in individuals with a life-threatening illness.

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