Skip to content

User perceptions of the benefits and harms of hallucinogenic drug use: A web-based questionnaire study

R. L. Carhart-Harris, D. J. Nutt

Journal of Substance Use July 30, 2010 DOI: 10.3109/14659890903271624 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Cross-sectional survey Peer reviewed
Sample size 600
Population Users of hallucinogenic drugs who completed a web-based questionnaire
Topics Addiction Cannabis LSD MDMA Psilocybin
Keywords Hallucinogen
Citations 108
Key findings Users reported less harm from classic hallucinogens (LSD, psilocybin) than from MDMA, cannabis, ketamine, and alcohol, and reported a range of benefits including help with mood disorders, addictions, and migraines.

Abstract

This study used a web-based questionnaire to investigate user perceptions of the benefits and harms of hallucinogenic drug use. Over 600 forms were submitted. Users were asked to comment on the acute and prolonged effects of different drugs and to provide more specific information on how particular drugs have harmed and/or helped them. Subjects reported relatively less harm associated with the classic hallucinogens, LSD and psilocybin, than other drugs specifically focused on in the questionnaire (MDMA, cannabis, ketamine and alcohol). A wide-range of benefits was reported, including: help with mood disorders, addictions and migraine as well as more general long-term improvements in wellbeing. Symptoms of hallucinogen persisting perceptual disorder were reported by a number of subjects and these were most closely associated with use of LSD; however, few users regarded these effects as troubling. Eighty-one per cent of users reported having had a 'spiritual experience' on a hallucinogenic drug and over 90% considered 'access to the unconscious mind' to be a specific property of the classic hallucinogens. With caution, these findings support recent calls for a systematic investigation of the therapeutic potential of the classic hallucinogens and highlight the scope for empirical investigations of spiritual and psychodynamic phenomena.

In the evidence

This study is part of the evidence base for 3 syntheses in the library. Here is how each one recorded it.

  • Users reported less harm from classic hallucinogens than from cannabis and other drugs, and reported benefits including help with addictions.

    Synthesized

  • Users reported less harm from classic hallucinogens (LSD, psilocybin) than from other drugs and reported a range of benefits including help with addictions.

    Synthesized

  • Users reported benefits including help with addictions, while reporting less harm from classic hallucinogens than from MDMA, cannabis, ketamine, and alcohol.

    Synthesized

Comparable studies

Other cross-sectional and survey studies on LSD for addiction, most cited first.

Study Year Design Participants
Increased use of illicit drugs in a Dutch cluster headache population People with cluster headache in the Netherlands 2018 Cross-sectional study n = 756
Epidemiology of classic psychedelic substances: results from a Norwegian internet convenience sample Norwegian adults who have had a memorable experience after taking a classic psychedelic... 2023 Cross-sectional survey n = 770
Assessing The Readiness of Psychiatrists in Louisiana to Incorporate Psilocybin into Clinical Practice—Lessons Learned from a State Underrepresented in Clinical Psychedelic Research Registered psychiatrists in Louisiana 2025 Survey n = 49
The Relationship Between Psychedelic Use and Alcohol Use Disorder in a Nationally Representative Sample. Nationally representative sample of US adults 2025 Observational cross-sectional study n = 139,524
Perceived outcomes of psychedelic microdosing as self-managed therapies for mental and substance use disorders. International online respondents with current or past experience of psychedelic... 2020 Cross-sectional survey n = 1,102

Explore topics

By condition and practice