Drugs and Phantasy: The Effects of LSD, Psilocybin and Sernyl on College Students
JAMA April 11, 1966 DOI: 10.1001/jama.1966.03100150141056 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Single-blind controlled experiment Randomized Peer reviewed |
|---|---|
| Sample size | 3 |
| Population | Three human subjects |
| Interventions | LSD psilocybin sernyl placebo |
| Duration | Three hours |
| Topics | LSD Psilocybin |
| Keywords | Hallucinogen Pharmacology |
| Citations | 7 |
| Key findings | LSD and psilocybin produced emotional lability, mental confusion, changes in ego boundaries, and colorful perceptual alterations, consistent with prior reports. |
Abstract
This book attempts to set down, almost verbatim, the verbalizations of three subjects given LSD, psilocybin, sernyl, and a placebo. The drugs were administered in a single-blind fashion under conditions of sensory monotony, namely, listening to noise and looking at a glazed white dome for three hours. What the authors hoped to achieve was to eliminate the extraneous factors of setting and set and to study the drug effects alone. Even in the restricted environment, this was hardly possible, for the subjects brought with them into the drug sessions their own many variables. Moods varied from week to week, and the nonrandomized order in which the four drugs were administered influenced certain aspects of each drug experience. The effects of LSD and psilocybin reflect the reports in the literature. Emotional lability, mental confusion, changes in ego boundaries, and the well-known colorful perceptual alterations are mentioned. Sernyl tends to evoke
Comparable studies
Other randomized controlled trials on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Safety and Efficacy of Lysergic Acid Diethylamide-Assisted Psychotherapy for Anxiety Associated With Life-threatening Diseases Patients with anxiety associated with life-threatening diseases | 2014 | Randomized controlled trial | n = 12 |
| Dose-Response Study of N,N-Dimethyltryptamine in Humans Experienced hallucinogen users | 1994 | Double-blind, saline placebo-controlled, randomized study | n = 12 |
| Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects Healthy subjects (8 women, 8 men) | 2014 | Double-blind, randomized, placebo-controlled, crossover study | n = 16 |
| Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor Healthy human participants | 2018 | Double-blind, randomized, counterbalanced, cross-over study | n = 24 |
| LSD-induced entropic brain activity predicts subsequent personality change. Healthy adults | 2016 | Balanced-order, placebo-controlled study | n = 19 |