Psilocybin-Assisted Compassion Focused Therapy for Depression
Wendy T. M. Pots, Farid Chakhssi
Frontiers in Psychology March 25, 2022 DOI: 10.3389/fpsyg.2022.812930 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Interventions | Psilocybin-assisted psychotherapy Compassion Focused Therapy |
| Topics | Meditation Psilocybin Depression |
| Keywords | Psychotherapist Compassion Hallucinogen Clinical psychology |
| Citations | 31 |
| Key points | Proposes that Compassion Focused Therapy can provide the theoretical model and compassion practices to reinforce experiences during psilocybin-assisted psychotherapy for depression. |
Abstract
Psilocybin-assisted psychotherapy, i.e., psilocybin treatment with psychological support, has demonstrated the efficacy of psilocybin to reduce depressive symptoms. However, in clinical trials, the structure of psilocybin-assisted psychotherapy is primarily based on preparation, navigation (support during dosing sessions), and integration. For psychotherapeutic guidance, the application of this structure is favored over the usage of theoretical models. The applied psychotherapeutic models may be of critical importance if the effects are augmented due to the psychologically insightful experiences during the navigation and integration sessions. One of the important next steps is to provide therapists with guidance on how to provide psilocybin-assisted psychotherapy. We present an integrated protocol for psilocybin-assisted psychotherapy for depression based on the theoretical model and psychotherapeutic framework of Compassion Focused Therapy (CFT). We hypothesize that CFT can provide the theoretical model and compassion practices that will reinforce the experiences during the navigation and follow-up therapy sessions. In this paper, we describe the rationale for selecting CFT, the compatibility of CFT and psilocybin-therapy, an overview of the psilocybin-assisted CFT protocol, the study protocol, and limitations to this approach.
Comparable studies
Other theoretical and historical papers on psilocybin and meditation, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Virtual Reality as a Moderator of Psychedelic-Assisted Psychotherapy | 2022 | Theoretical or philosophical paper | |
| Psilocybin: The most effective moral bio‐enhancer? | 2023 | Theoretical or philosophical paper | |
| Preparing the body for psilocybin therapy: receptive and generative interoception in cancer patients | 2026 | Theoretical or philosophical paper |
Citations in the library
Cited by 24
- The effect of psilocybin on empathy and prosocial behavior: a proposed mechanism for enduring antidepressant effects. npj Mental Health Research February 20, 2024
- Protocols and practices in psilocybin assisted psychotherapy for depression: A systematic review. Journal of Psychiatric Research August 1, 2024
- Classic psychedelic use and current meditation practice. Mindfulness April 1, 2023
- The Emergence of Psilocybin in Psychiatry and Neuroscience Pharmaceuticals April 9, 2025
- EMBARK Psychedelic Therapy for Depression March 6, 2024
and 19 more in the library
Cites 31
- Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial Journal of Psychopharmacology November 30, 2016
- Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial Journal of Psychopharmacology November 30, 2016
- Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance Psychopharmacology July 7, 2006
- Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study. The Lancet Psychiatry May 17, 2016
- Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder JAMA Psychiatry November 4, 2020
and 26 more in the library