Pharmacologic Activity of Substituted Tryptamines at 5-Hydroxytryptamine (5-HT)2A Receptor (5-HT2AR), 5-HT2CR, 5-HT1AR, and Serotonin Transporter.

Study at a glance

Characteristics	In vitro assay Peer reviewed
Intervention	substituted tryptamines
Topics	Serotonin
Keywords	Drug design Medicinal chemistry Therapeutics Neuropharmacology: psychopharmacology Cns research Neurobiology Brain chemistry Serotonergic system Receptor binding Tryptamines: indoleamines Serotonin analogs
Citations	40
Key points	5-methoxy-substituted tryptamines, particularly 5-MeO-DMT and 5-MeO-tryptamine, are potent agonists at 5-HT2AR and 5-HT2CR, with weak activity at 5-HT1AR and the serotonin transporter.

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