Group psychedelic therapy: empirical estimates of cost-savings and improved access
Elliot Marseille, Manish Agrawal, Paul Thambi, Kimberly Roddy, Christopher S. Stauffer, Michael C Mithoefer, Stefano Bertozzi, James G. Kahn
Frontiers in Psychiatry December 6, 2023 DOI: 10.3389/fpsyt.2023.1293243 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Comparative cost analysis using trial data and published estimates Peer reviewed |
|---|---|
| Population | Adults with PTSD or major depressive disorder eligible for psychedelic-assisted therapy in the U.S. |
| Intervention | Individual psychedelic-assisted therapy |
| Topics | Depression MDMA Psilocybin Psychedelic-assisted therapy |
| Keywords | Group psychotherapy Exposure therapy |
| Citations | 40 |
| Key findings | Group psychedelic-assisted therapy reduces clinician costs by 50.9% for MDMA-PTSD and 34.7% for psilocybin-MDD, potentially saving billions and reducing clinician demand. |
Abstract
Objective: To compare group and individual psychedelic-assisted therapy in terms of clinician time, costs and patient access.
Methods: Using 2023 data from two group therapy trial sites, one using 3,4-Methylenedioxymethamphetamine (MDMA) to treat posttraumatic stress disorder (PTSD), and one using psilocybin to treat major depressive disorder (MDD), we compared overall variable costs, clinician costs and clinician time required by therapy protocols utilizing groups versus individual patient therapy. Using published literature, we estimated the prevalence of adults with PTSD and MDD eligible for treatment with psychedelic therapy and projected the savings in time and cost required to treat these prevalent cases.
Results: Group therapy saved 50.9% of clinician costs for MDMA-PTSD and 34.7% for psilocybin-MDD, or $3,467 and $981 per patient, respectively. To treat all eligible PTSD and MDD patients in the U.S. in 10 years with group therapy, 6,711 fewer full-time equivalent (FTE) clinicians for MDMA-PTSD and 1,159 fewer for FTE clinicians for psilocybin-MDD would be needed, saving up to $10.3 billion and $2.0 billion respectively, discounted at 3% annually.
Conclusion: Adopting group therapy protocols where feasible would significantly reduce the cost of psychedelic-assisted therapies. By enhancing the number of patients served per clinician, group therapy could also ameliorate the anticipated shortage of appropriately trained clinicians, thereby accelerating access to these promising new therapies.
In the evidence
This study is part of the evidence base for a synthesis in the library. Here is how each one recorded it.
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Group psychedelic-assisted therapy reduced clinician costs by 50.9% for MDMA-PTSD and 34.7% for psilocybin-MDD, potentially improving access.
Synthesized
Comparable studies
Other non-randomized and open-label trials on MDMA for depression, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Study protocol for “MDMA-assisted therapy as a treatment for major depressive disorder: A proof of principle study” Participants with DSM-5 diagnosis of major depressive disorder | 2022 | Open-label clinical trial | n = 12 |
| MDMA-assisted therapy as a treatment for major depressive disorder: proof of principle study. Adults with moderate to severe major depressive disorder | 2025 | Open-label study | n = 12 |
| MDMA-assisted therapy for major depressive disorder: A seven-month follow-up proof of principle trial Participants with major depressive disorder and an ongoing moderate to severe... | 2025 | Long-term follow-up of a clinical trial | n = 12 |
Citations in the library
Cited by 32
- Psychedelics and the treatment of eating disorders: considerations for future research and practice. Journal of Eating Disorders October 22, 2024
- Psychedelic-assisted therapy as a complex intervention: implications for clinical trial design Therapeutic Advances in Psychopharmacology September 1, 2025
- Psilocybin-assisted therapy for treatment-resistant depression in the US: a model-based cost-effectiveness analysis Translational Psychiatry August 29, 2025
- Psychedelic medicine: mechanisms, evidence, and translation to practice BMJ February 23, 2026
- Psilocybin-assisted group psychotherapy and mindfulness-based stress reduction for frontline healthcare provider COVID-19-related depression and burnout: A randomized controlled trial PLoS Medicine September 19, 2025
and 27 more in the library
Cites 16
- Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial Journal of Psychopharmacology November 30, 2016
- Trial of Psilocybin versus Escitalopram for Depression New England Journal of Medicine April 14, 2021
- Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder JAMA Psychiatry November 4, 2020
- MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study. Nature Medicine June 1, 2021
- Long-term follow-up of psilocybin-facilitated smoking cessation The American Journal of Drug and Alcohol Abuse July 21, 2016
and 11 more in the library