Double-Blind Comparison of the Two Hallucinogens Dextromethorphan and Psilocybin: Experience-Dependent and Enduring Psychological Effects in Healthy Volunteers
Samantha Hilbert, David S. Mathai, Nathan D. Sepeda, Justin C Strickland, Roland R. Griffiths, Albert Garcia‐romeu
Psychedelic Medicine August 30, 2023 DOI: 10.1089/psymed.2023.0035 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Analysis Double-blind Peer reviewed |
|---|---|
| Topics | Psilocybin |
| Keywords | Dextromethorphan Hallucinogen Psychotherapist Clinical psychology |
| Citations | 10 |
| Registration | NCT02033707 |
| Key points | Dissociatives may have clinical utility when explored within supportive contexts characteristic of psychedelic research. |
Abstract
This analysis suggests the utility of exploring clinical applications of dissociatives that occur within the supportive contexts that are characteristic of psychedelic research and that prioritize the optimization of psychologically valuable drug experiences. This study was registered with ClinicalTrials.gov (NCT02033707).
Citations in the library
Cited by 11
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- Addressing blinding in classic psychedelic studies with innovative active placebos. The International Journal of Neuropsychopharmacology April 1, 2025
- At-home, telehealth-supported ketamine treatment for depression: Findings from longitudinal, machine learning and symptom network analysis of real-world data. Journal of Affective Disorders September 15, 2024
- Shame, Guilt and Psychedelic Experience: Results from a Prospective, Longitudinal Survey of Real-World Psilocybin Use Journal of Psychoactive Drugs February 7, 2025
- Learning how to make use of dissociative therapies. International Review of Psychiatry December 1, 2024
and 6 more in the library
Cites 43
- Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance Psychopharmacology July 7, 2006
- Human hallucinogen research: guidelines for safety. Journal of Psychopharmacology July 1, 2008
- Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects. Psychopharmacology December 1, 2011
- Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression Frontiers in Pharmacology January 17, 2018
- Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation American Journal of Psychiatry March 17, 2021
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