Local field potential changes during euthanasia may parallel with near death experience.
Julieta Trejo, Kaitlin M Killian, Zhen Wang, Yuan B Peng
Scientific Reports April 3, 2025 DOI: 10.1038/s41598-025-92723-0 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | CO2 euthanasia |
| Topics | Near-death experience |
| Keywords | Dying brain Local field potential Out-of-body experience Power spectral changes |
| Citations | 1 |
| Key findings | Freely-moving rats exhibited a rebound spike in local field potential power across all frequency bands three minutes after CO2 initiation, followed by a general decrease, while anesthetized rats showed only a general decrease with less rebound activity. |
Abstract
A global experience that every human life meets is death. For several decades, individuals have reported their unique encounters with near-death experience (NDE), which has raised many unanswered questions. In the present experiment, we utilize continuous local field potential (LFP) during the euthanasia process to show the dynamic changes of frequency band power in four distinct regions of the rat brain from intracranially implanted electrodes: the right anterior cingulate cortex (ACC), right thalamus (Po), left trigeminal ganglion (TG), and the right primary visual cortex (V1M). At the end of a separate migraine study, two groups of rats underwent the euthanasia process: freely-moving and anesthetized. The findings from the current study indicate that (1) in the freely-moving group, a rebound spike in LFP was observed in all five frequency bands 3-minutes after CO2 initiation, followed by a general decrease of power; (2) in the anesthetized group, a general decrease of power in all five frequency bands was observed during the CO2 euthanasia, with less rebound activities; (3) high correlation among these five frequency band powers from the four designated brain regions were observed. The rebound surge observed in the freely-moving group may help us understand the NDE phenomenon. Perhaps the profound experiences reported at the end of life emerge during the brain's final surges of activity.
Comparable studies
Other preclinical and animal studies on near-death experience, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Identifying neuronal correlates of dying and resuscitation in a model of reversible brain anoxia. Rodents | 2020 | Experimental animal model | |
| Surge of neurophysiological coherence and connectivity in the dying brain. Rats | 2013 | Experimental study |
Citations in the library
Cites 19
- Near-death experience in survivors of cardiac arrest: a prospective study in the Netherlands The Lancet December 1, 2001
- The Near-death Experience The British Journal of Psychiatry November 1, 1988
- The effect of carbon dioxide on near-death experiences in out-of-hospital cardiac arrest survivors: a prospective observational study Critical Care April 8, 2010
- Near-death experiences in cardiac arrest survivors Progress in Brain Research 2005
- Brain activity in near-death experiencers during a meditative state Resuscitation July 2, 2009
and 14 more in the library