Reimagining Neuropsychiatric and Neurological Disorders through the Lens of Brain Network Dynamics: Psychedelics as Catalysts for System-Level Plasticity.
Cong Zhang, Yibo Wang, Xiaohui Wang
ACS Pharmacology & Translational Science July 11, 2025 DOI: 10.1021/acsptsci.5c00379 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Topics | Neuroplasticity |
| Keywords | Brain entropy Brain networks Circuit remodeling Neuropsychiatric disorders Psychedelics |
| Citations | 2 |
| Key points | Proposes that psychedelics may therapeutically increase neural entropy, disrupt maladaptive patterns, and promote network reorganization, emphasizing dynamic connectome remodeling over static molecular correction. |
Abstract
Neuropsychiatric disorders reflect disruptions in brain network dynamics along an "order-complexity-chaos" continuum. Psychedelics may therapeutically increase neural entropy, disrupt maladaptive patterns, and promote network reorganization. This system-level framework emphasizes dynamic connectome remodeling over static molecular correction, offering a novel strategy for treating psychiatric and neurological conditions through controlled neural destabilization and reconnection.
Comparable studies
Other theoretical and historical papers on neuroplasticity, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| A Dendrite-Focused Framework for Understanding the Actions of Ketamine and Psychedelics | 2020 | Theoretical or philosophical paper | |
| Does Psychedelic Therapy Have a Transdiagnostic Action and Prophylactic Potential? | 2021 | Theoretical or philosophical paper | |
| A complex systems perspective on psychedelic brain action. | 2023 | Theoretical or philosophical paper | |
| Critical Period Plasticity as a Framework for Psychedelic-Assisted Psychotherapy | 2021 | Theoretical or philosophical paper | |
| Therapeutic mechanisms of psychedelics and entactogens. | 2023 | Theoretical or philosophical paper |
Citations in the library
Cited by 2
- Effective connectivity of the human claustrum: Triple networks, subcortical circuits, and psychedelic modulation bioRxiv (Cold Spring Harbor Laboratory) September 12, 2025
- Effects of naturalistic psychedelic use on executive functioning: An online survey of lifetime history and recent use in university students. Progress in Neuro-Psychopharmacology and Biological Psychiatry August 11, 2026
Cites 8
- Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study. The Lancet Psychiatry May 17, 2016
- REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics Pharmacological Reviews June 20, 2019
- Psychedelics Promote Structural and Functional Neural Plasticity Cell Reports June 1, 2018
- Psychedelics reopen the social reward learning critical period Nature June 14, 2023
- Transient Stimulation with Psychoplastogens Is Sufficient to Initiate Neuronal Growth ACS Pharmacology & Translational Science September 11, 2020
and 3 more in the library