Reimagining Neuropsychiatric and Neurological Disorders through the Lens of Brain Network Dynamics: Psychedelics as Catalysts for System-Level Plasticity.
Cong Zhang, Yibo Wang, Xiaohui Wang
ACS Pharmacology & Translational Science July 11, 2025 DOI: 10.1021/acsptsci.5c00379 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Topics | Neuroplasticity |
| Keywords | Brain entropy Brain networks Circuit remodeling Neuropsychiatric disorders Psychedelics |
| Citations | 2 |
| Key points | Proposes that psychedelics may therapeutically increase neural entropy, disrupt maladaptive patterns, and promote network reorganization, emphasizing dynamic connectome remodeling over static molecular correction. |
Abstract
Neuropsychiatric disorders reflect disruptions in brain network dynamics along an "order-complexity-chaos" continuum. Psychedelics may therapeutically increase neural entropy, disrupt maladaptive patterns, and promote network reorganization. This system-level framework emphasizes dynamic connectome remodeling over static molecular correction, offering a novel strategy for treating psychiatric and neurological conditions through controlled neural destabilization and reconnection.