Mindfulness-Based Cognitive Therapy for Treatment-Resistant Depression: A protocol for systematic review and meta-analysis.
Michele F. Rodrigues, Larissa Junkes, Jose Appolinario, Antonio E Nardi
PLoS One 2024 DOI: 10.1371/journal.pone.0306227 (opens in new tab)
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Study at a glance
AI-extracted from the abstract| Characteristics | Systematic review protocol Randomized Peer reviewed |
|---|---|
| Population | Adults with Treatment-Resistant Depression |
| Intervention | Mindfulness-Based Cognitive Therapy |
| Topics | Depression Meditation |
| Citations | 5 |
| Key findings | The review aims to determine whether MBCT is more effective than standard care or other active treatments in reducing depressive symptoms and whether its safety profile is comparable. |
Abstract
Major Depressive Disorder (MDD) is a global health issue, and a significant portion of individuals with MDD experience Treatment-Resistant Depression (TRD), characterized by the lack of response to adequately trialed antidepressant medication and therapy. This systematic review aims to investigate the effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) as an intervention for individuals with TRD. We will conduct a thorough search for publications of randomized clinical trials and quasi-experimental studies in MEDLINE, Embase, PsycINFO, Web of Science databases, and ClinicalTrials.gov. Furthermore, reference lists of included studies will be manually screened for additional relevant articles, with no restrictions on language or publication date. The search will be conducted from the inception of the databases until June 2024. Our PICO-guided research questions are: (1) In adults with Treatment-Resistant Depression, is MBCT more effective than standard care or other active treatments in reducing depressive symptoms? (2) In adults with Treatment-Resistant Depression, does MBCT demonstrate a comparable safety profile to standard care or other active treatments? The quality of the included studies will be assessed independently using the Cochrane Risk of Bias Tool (RoB 2). This study seeks to evaluate the effectiveness and tolerability of Mindfulness-Based Cognitive Therapy as an intervention for Treatment-Resistant Depression, and will employ the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology to appraise the confidence in the evidence. Prospero registration ID: CRD42023411978. Registered on April 07, 2023.
Comparable studies
Other systematic reviews and meta-analyses on depression, most cited first.
Citations in the library
Cited by 2
- Mindfulness-Based Counseling as an Intervention for Reducing Anxiety and Depression Symptoms Journal of Education, Humanities and Social Sciences February 5, 2026
- Correction: Mindfulness-Based Cognitive Therapy for Treatment-Resistant Depression: A protocol for systematic review and meta-analysis. PLoS One December 26, 2024
Cites 8
- Using Self-Report Assessment Methods to Explore Facets of Mindfulness Assessment January 27, 2006
- Mindfulness-Based Stress Reduction for Stress Management in Healthy People: A Review and Meta-Analysis The Journal of Alternative and Complementary Medicine May 1, 2009
- Mindfulness-based cognitive therapy for depression August 21, 2006
- Mindfulness-based cognitive therapy as a treatment for chronic depression: A preliminary study Behaviour Research and Therapy February 13, 2009
- A Randomized Controlled Trial of Mindfulness-Based Cognitive Therapy for Treatment-Resistant Depression Psychotherapy and Psychosomatics 2016
and 3 more in the library