The effects of psilocybin on cognition and emotional processing in healthy adults and adults with depression: a systematic literature review
Laura Ramos, Selene G Vicente
Journal of Clinical and Experimental Neuropsychology May 27, 2024 DOI: 10.1080/13803395.2024.2363343 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Longitudinal Peer reviewed |
|---|---|
| Intervention | Psilocybin |
| Topics | Psilocybin Depression |
| Keywords | Cognition Depression disorder Emotional processing Healthy adults Psychedelic medicine Hallucinogenic compounds Psychiatric treatment Behavioral health Mental flexibility Thinking patterns |
| Citations | 5 |
| Key findings | Psilocybin acutely alters several cognitive domains in a dose- and time-dependent manner with a localized rather than global focus. |
Abstract
Psilocybin acutely alters several cognitive domains, with a localized rather than global focus, in a dose- and time-dependent manner. However, the significant methodological constraints call for further research, in the context of depression and with standardized protocols, with longitudinal studies also imperative.
Comparable studies
Other narrative reviews on psilocybin for depression, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function. General population | 2019 | Integrative review | |
| Molecular Mechanisms of Psilocybin and Implications for the Treatment of Depression | 2021 | Review | |
| Registered clinical studies investigating psychedelic drugs for psychiatric disorders. Registered clinical trials on clinicaltrials.gov evaluating psychedelics for... | 2021 | Review | n = 70 |
| Depression, Mindfulness, and Psilocybin: Possible Complementary Effects of Mindfulness Meditation and Psilocybin in the Treatment of Depression. A Review | 2020 | Review | |
| From psychiatry to neurology: Psychedelics as prospective therapeutics for neurodegenerative disorders | 2021 | Review |