Opposite effects of 5-methoxy-N,N-di-methyl-tryptamine and 5-hydroxytryptophan on male rat sexual behavior.
Pharmacology, biochemistry, and behavior 1991 DOI: 10.1016/0091-3057(91)90611-5 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Male rats |
| Interventions | 5-MeODMT pindolol pirenperone metergoline 5-HTP benserazide betaxolol |
| Dose | 5-MeODMT 1 mg.kg-1 SC; pindolol 4 mg.kg-1 SC; pirenperone 0.25 mg.kg-1 SC; metergoline 1 mg.kg-1 SC; 5-HTP 25 mg.kg-1 SC; benserazide 25 mg.kg-1 SC; betaxolol 8 mg.kg-1 SC |
| Topics | 5-MeO-DMT |
| Citations | 31 |
| Key findings | Stimulation of brain 5-HT1 receptors facilitates male rat sexual behavior, while stimulation of 5-HT2 receptors inhibits it. |
Abstract
The administration of 5-methoxy-N,N-di-methyl-tryptamine (5-MeODMT), O-2.0 mg.kg-1 SC -15 min, produced a dose-dependent facilitation of the male rat sexual behavior, as evidenced by a decrease in the number of intromissions to ejaculation and in the ejaculation latency. The effects produced by 5-MeODMT (1 mg.kg-1) were antagonized by pindolol (4 mg.kg-1 SC -30 min), but not pirenperone (0.25 mg.kg-1 SC -30 min) or metergoline (1 mg.kg-1 SC -30 min), administration. As expected, 5-HTP (25 mg.kg-1 SC -60 min) produced an increased number of mounts and intromissions to ejaculation and an increase in the ejaculation latency in benserazide (25 mg.kg-1 SC -90 min) pretreated animals. Pindolol (4 mg.kg-1) by itself produced the same effects as seen after 5-HTP administration, and the combination of these compounds produced additive effects. Betaxolol (8 mg.kg-1 SC -30 min) had no effects of its own and did not interact with 5-HTP. The results suggest that stimulation of brain 5-HT1 or 5-HT2 receptors produces facilitation and inhibition, respectively, of the male rat sexual behavior.