Intracellular studies on the effects of systemic administration of serotonin agonists on rat facial motoneurons.
C P Vandermaelen, George K. Aghajanian
European Journal of Pharmacology February 26, 1982 DOI: 10.1016/0014-2999(82)90242-4 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Facial motoneurons of anesthetized rats |
| Interventions | 5-MeODMT PCA |
| Topics | Serotonin |
| Citations | 37 |
| Key findings | Systemic administration of 5-MeODMT and PCA causes slow depolarization, increased input resistance, and increased excitability of facial motoneurons, identical to the effects of direct serotonin application. |
Abstract
Intracellular recordings were made from facial motoneurons of anesthetized rats during systemic administration of 5-methoxy-N,-N-dimethyltryptamine (5-MeODMT) and p-chloroamphetamine (PCA), drugs which elicit the behavioral serotonin syndrome. Both drugs caused a slow depolarization, increased input resistance, and increased excitability of facial motoneurons. These changes are identical to those caused by direct microiontophoretic application of serotonin to these neurons, and probably underlie some of the components of the behavioral serotonin syndrome.
Comparable studies
Other preclinical and animal studies on serotonin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo Mice | 2021 | Observational cohort | |
| Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. Rats (implied by typical neurochemical study context) | 1987 | Experimental study | |
| Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors In vitro and in vivo (rodent) models | 2023 | Experimental study | |
| 3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites. Rat brain | 1987 | Animal experiment | |
| Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs Human and mouse dopamine, norepinephrine, and serotonin transporters expressed in cells | 2006 | In vitro laboratory study |
Citations in the library
Cited by 3
- Potentiation of motoneurone excitability by combined administration of 5-HT agonist and TRH analogue. Neuropeptides June 1, 1985
- The excitability and rhythm of medullary respiratory neurons in the cat are altered by the serotonin receptor agonist 5-methoxy-N,N, dimethyltryptamine. Brain Research June 13, 1994
- Stimulatory and inhibitory effects of serotonergic hallucinogens on spinal mono- and polysynaptic reflex pathways in the rat. Neuropharmacology July 1, 1992