Intracellular studies on the effects of systemic administration of serotonin agonists on rat facial motoneurons.
C P Vandermaelen, George K. Aghajanian
European Journal of Pharmacology February 26, 1982 DOI: 10.1016/0014-2999(82)90242-4 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Facial motoneurons of anesthetized rats |
| Interventions | 5-MeODMT PCA |
| Topics | Serotonin |
| Citations | 37 |
| Key findings | Systemic administration of 5-MeODMT and PCA causes slow depolarization, increased input resistance, and increased excitability of facial motoneurons, identical to the effects of direct serotonin application. |
Abstract
Intracellular recordings were made from facial motoneurons of anesthetized rats during systemic administration of 5-methoxy-N,-N-dimethyltryptamine (5-MeODMT) and p-chloroamphetamine (PCA), drugs which elicit the behavioral serotonin syndrome. Both drugs caused a slow depolarization, increased input resistance, and increased excitability of facial motoneurons. These changes are identical to those caused by direct microiontophoretic application of serotonin to these neurons, and probably underlie some of the components of the behavioral serotonin syndrome.