Altered responses to serotonergic agents in Fawn-Hooded rats.
Gary A. Gudelsky, J I Koenig, Herbert Y. Meltzer
Pharmacology, Biochemistry, and Behavior March 1, 1985 DOI: 10.1016/0091-3057(85)90052-8 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Population | Fawn-Hooded and Sprague-Dawley rats |
| Interventions | quipazine 5-methoxy-N N-dimethyltryptamine (5MeODMT) 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) |
| Topics | Serotonin |
| Citations | 54 |
| Key findings | Fawn-Hooded rats show significantly greater behavioral responses to quipazine and 5MeODMT but a significantly weaker hypothermic response to 8-OH-DPAT compared to Sprague-Dawley rats. |
Abstract
The incidence of "wet dog" shakes elicited by quipazine, the hyperthermic response induced by 5-methoxy-N,N-dimethyltryptamine (5MeODMT) and the hypothermic response to 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) were compared in rats of the Fawn-Hooded (FH) and Sprague-Dawley (SD) strains. The behavioral responses of FH rats to quipazine and 5MeODMT were significantly greater than those of SD rats. On the other hand, the hypothermic effect of 8-OH-DPAT in FH rats was significantly less than that elicited in SD animals. The present results are supportive of the view that the responsiveness of serotonergic mechanisms in the CNS of FH rats differs markedly from those in SD animals.
Comparable studies
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| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo Mice | 2021 | Observational cohort | |
| Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. Rats (implied by typical neurochemical study context) | 1987 | Experimental study | |
| Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors In vitro and in vivo (rodent) models | 2023 | Experimental study | |
| 3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites. Rat brain | 1987 | Animal experiment | |
| Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs Human and mouse dopamine, norepinephrine, and serotonin transporters expressed in cells | 2006 | In vitro laboratory study |
Citations in the library
Cited by 4
- A narrative synthesis of research with 5-MeO-DMT. Journal of Psychopharmacology March 1, 2022
- Modulation of high alcohol drinking in the inbred Fawn-Hooded (FH/Wjd) rat strain: implications for treatment. Addiction Biology September 1, 2006
- MDMA-like stimulus effects of hallucinogens in male Fawn-Hooded rats. Pharmacology, Biochemistry, and Behavior February 1998
- Attenuation of alcohol consumption by MDMA (ecstasy) in two strains of alcohol-preferring rats. Pharmacology, Biochemistry, and Behavior September 1, 1992