Behavioral reactivity following 5-MeODMT administration in 5,7-DHT-pretreated killer rats.
G R Cuadra, V A Molina
Pharmacology, Biochemistry, and Behavior June 1, 1990 DOI: 10.1016/0091-3057(90)90405-7 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats classified as grouped, nonkiller, and killer |
| Intervention | 5 |
| Duration | 7-10 days |
| Citations | 4 |
| Key findings | Killer rats showed a reduced increase in serotonin-induced behaviors after destruction of serotonin fibers compared to nonkiller and grouped rats, despite comparable reductions in serotonin uptake. |
Abstract
Grouped, nonkiller and killer animals were centrally injected either with vehicle or with 5,7-dihydroxytryptamine. After a period of 7-10 days, forepaw treading and hindlimb abduction were induced by 5-MeODMT administration in all sham and lesioned rats. As expected, behavioral supersensitivity was observed in grouped and nonkiller lesioned rats. A reduced increase in 5-MeODMT-induced behaviors was obtained in killer lesioned animals. 5-HT uptake studies showed a comparable reduction of 5-HT uptake within all the lesioned rats. This evidence suggests an altered capacity to promote adaptive changes on 5-HT sites in killer rats following the destruction of central serotonergic fibers.
Citations in the library
Cites 2
- Subtypes of the 5-HT receptor mediating the behavioural responses to 5-methoxy-N,N-dimethyltryptamine in the rat European Journal of Pharmacology October 1, 1985
- Increased behavioural response to 5-methoxy-N,N-dimethyltryptamine but not to RU-24969 after intraventricular 5,7-dihydroxytryptamine administration. European Journal of Pharmacology September 3, 1984