Skip to content

Differential effects of 5-hydroxytryptamine1a selective drugs on the 5-HT behavioral syndrome.

L M Smith, S J Peroutka

Pharmacology, Biochemistry, and Behavior June 1, 1986 DOI: 10.1016/0091-3057(86)90477-6 (opens in new tab)

Read Full Text
Relevant Not relevant

Study at a glance

AI-extracted from the abstract
Characteristics Observational study Peer reviewed
Population Rat
Interventions 8-OH-DPAT 5-MeODMT buspirone isapirone
Topics Serotonin
Citations 245
Key findings 8-OH-DPAT and 5-MeODMT act as full agonists for six components of the 5-HT behavioral syndrome, while buspirone and isapirone antagonize forepaw treading, head-weaving, and tremor but not other behaviors.

Abstract

The effects of 8-hydroxy-2-(di-n-propyl-amino) tetralin (8-OH-DPAT), 5-methoxy-N,N-dimethyltryptamine (5-MeODMT), buspirone and isapirone were examined at 5-hydroxytryptamine1A (5-HT1A) binding sites and on the 5-HT behavioral syndrome in the rat. 8-OH-DPAT, 5-MeODMT, buspirone and isapirone are all potent inhibitors of 3H-8-OH-DPAT binding to rat brain membranes (Ki values = 1.9-13 nM). However, these drugs have differential effects on the 5-HT behavioral syndrome. 8-OH-DPAT, 5-MeODMT and buspirone induce hindlimb abduction, flattened body posture and Straub tail. Isapirone induces only a slight flattening of body posture. By contrast, 8-OH-DPAT and 5-MeODMT, but not buspirone and isapirone, and isapirone, also induce forepaw treading, head-weaving and tremor. However, both buspirone and isapirone antagonize the induction of these three behaviors by 8-OH-DPAT or 5-MeODMT. These data show that 8-OH-DPAT and 5-MeODMT are "full agonists" in relation to six components of the 5-HT behavioral syndrome. Buspirone and isapirone, on the other hand, act as "antagonists" in relation to forepaw treading, head-weaving and tremor. Therefore, these data suggest that specific components of the 5-HT behavioral syndrome are mediated by 5-HT1A receptors.

Comparable studies

Other observational and cohort studies on serotonin, most cited first.

Study Year Design Participants
Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels Healthy volunteers 2019 Observational cohort n = 8
Memory impairment in abstinent MDMA ("Ecstasy") users Abstinent MDMA users 1998 Observational cohort
Dynamic coupling of whole-brain neuronal and neurotransmitter systems Healthy humans 2020 Observational study
The Serotonin System and Spiritual Experiences Normal male subjects, ages 20-45 years 2003 Observational cohort n = 15
Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD. Healthy human participants 2018 Observational study with computational modeling

Citations in the library

Cited by 15

and 10 more in the library

Cites 4

Related reading

Explore topics

Serotonin 5-MeO-DMT DMT