Role of hippocampal 5-HT1A receptors on elevated plus maze exploration after a single restraint experience.
S M Netto, Francisco S Guimarães
Behavioural Brain Research May 1, 1996 DOI: 10.1016/0166-4328(95)00211-1 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental animal study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | 5-MeODMT (+)WAY-100135 |
| Dose | 20 nmol/0.5 microliter (5-MeODMT); 40 nmol/0.5 microliter ((+)WAY-100135) |
| Topics | Serotonin |
| Citations | 45 |
| Key findings | Microinjection of 5-MeODMT into the dorsal hippocampus immediately after restraint stress increased open arm exploration 24 hours later, an effect blocked by a 5-HT1A antagonist, suggesting hippocampal 5-HT1A receptors attenuate stress behavioral consequences. |
Abstract
Previous studies have shown that 2 h restraint stress induces deficits in open arm exploration of an elevated plus maze 24 h later. This effect was attenuated by a post-stress systemic injection of the 5-HT non-selective agonist, 5-methoxy-N,N-dimethyltryptamine (5-MeODMT). To verify a possible involvement of hippocampal 5-HT1A receptors in this effect, rats were stereotaxically implanted with canulae in the dorsal hippocampus. Seven days later they received bilateral microinjections of 5-MeODMT (20 nmol/0.5 microliter) or saline. No difference was found on exploration of an elevated plus maze 24 h later. However, when treatments were performed immediately after 2 h of restraint stress, the drug was able to increase open arm exploration 24 h later. This effect was antagonized by a previous microinjection of (+)WAY-100135 (40 nmol/0.5 microliter), a selective 5-HT1A antagonist. The results suggest that hippocampal 5-HT1A receptors may attenuate stress behavioral consequences.
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