Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes.
Daniele Passarella, Raffaele Favia, Alessandra Giardini, Giordano Lesma, Marisa Martinelli, Alessandra Silvani, Bruno Danieli, Simon M. N. Efange, Deborah C. Mash
Bioorganic & Medicinal Chemistry March 20, 2003 DOI: 10.1016/s0968-0896(02)00524-2 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Topics | Ibogaine |
| Citations | 23 |
| Key points | Describes the synthesis and reports binding affinities of novel compounds for ibogaine-related receptors. |
Abstract
Synthesis of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes by cycloaddition and subsequent cross-coupling reaction is described. Binding affinity of these novel compounds towards the characteristic receptorial targets of ibogaine is illustrated.
Comparable studies
Other theoretical and historical papers on ibogaine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Biosynthesis of an Anti-Addiction Agent from the Iboga Plant. | 2019 | Theoretical or philosophical paper | |
| Bioinspired Collective Syntheses of Iboga-Type Indole Alkaloids. | 2016 | Theoretical or philosophical paper | |
| Fatalities after taking ibogaine in addiction treatment could be related to sudden cardiac death caused by autonomic dysfunction. Humans | 2006 | Theoretical or philosophical paper | |
| Iboga Alkaloids. II.1 the Structures of Ibogaine, Ibogamine and Tabernanthine | 1957 | Theoretical or philosophical paper | |
| Understanding the Healing Potential of Ibogaine through a Comparative and Interpretive Phenomenology of the Visionary Experience | 2018 | Theoretical or philosophical paper |
Citations in the library
Cited by 2
- Deconstructing the Iboga Alkaloid Skeleton: Potentiation of FGF2-induced Glial Cell Line-Derived Neurotrophic Factor Release by a Novel Compound. ACS Chemical Biology January 15, 2016
- Nature-inspired indolyl-2-azabicyclo[2.2.2]oct-7-ene derivatives as promising agents for the attenuation of withdrawal symptoms: synthesis of 20-desethyl-20-hydroxymethyl-11-demethoxyibogaine. Natural Product Research July 10, 2006
Cites 10
- Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum. Brain Research September 19, 1994
- Inhibitory effects of ibogaine on cocaine self-administration in rats. European Journal of Pharmacology September 14, 1993
- Attenuation of alcohol intake by ibogaine in three strains of alcohol-preferring rats. Pharmacology, Biochemistry, and Behavior November 1, 1995
- Acute and prolonged effects of ibogaine on brain dopamine metabolism and morphine-induced locomotor activity in rats. Brain Research March 13, 1992
- Ibogaine reduces preference for cocaine consumption in C57BL/6By mice. Pharmacology, Biochemistry, and Behavior 1994
and 5 more in the library