Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes.
Daniele Passarella, Raffaele Favia, Alessandra Giardini, Giordano Lesma, Marisa Martinelli, Alessandra Silvani, Bruno Danieli, Simon M. N. Efange, Deborah C. Mash
Bioorganic & medicinal chemistry March 20, 2003 DOI: 10.1016/s0968-0896(02)00524-2 (opens in new tab) via PubMed
Summary
AI-generated from the abstractA method to synthesize 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes using cycloaddition followed by cross-coupling is described. The binding affinity of these new compounds to the receptor targets characteristic of ibogaine is reported.
Study at a glance
| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Citations | 23 |
| Key finding | Describes the synthesis and reports binding affinities of novel compounds for ibogaine-related receptors. |
Abstract
Synthesis of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes by cycloaddition and subsequent cross-coupling reaction is described. Binding affinity of these novel compounds towards the characteristic receptorial targets of ibogaine is illustrated.