Pretreatment with the putative anti-addictive drug, ibogaine, increases the potency of cocaine to elicit locomotor responding: a study with acute and chronic cocaine-treated rats.
Karen K. Szumlinski, Isabelle M Maisonneuve, Stanley D Glick
Psychopharmacology July 1, 1999 DOI: 10.1007/s002130051053 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | Ibogaine Cocaine |
| Dose | 40 mg/kg ibogaine; 15 mg/kg cocaine for chronic treatment; 0, 5, 10, 20, 40 mg/kg cocaine for dose-response test |
| Duration | 5-day chronic treatment, 2-week withdrawal, 19 h after ibogaine pretreatment |
| Topics | Ibogaine |
| Keywords | Ibogaine pretreatment Cocaine Lower doses Higher doses Drug interaction Influences movement responses Amplified stimulating effects Complex interplay Animal model Rats Acute drug exposure Chronic drug exposure Prior drug history |
| Citations | 14 |
| Key findings | Ibogaine pretreatment enhances sensitivity to cocaine's locomotor stimulant effects, with the effect depending on prior cocaine history and cocaine dose. |
Abstract
Results of single-dose studies suggest that the effects of pretreatment with the putative anti-addictive compound, ibogaine, on drug-induced locomotor behavior depends on the previous drug history of the animal. To compare the effects of ibogaine pretreatment on the dose-locomotor response function for cocaine in rats treated chronically with either saline or cocaine. Rats were chronically treated with either cocaine (15 mg/kg, IP, once daily for 5 days, followed by 2 week withdrawal) or saline. Ibogaine (40 mg/kg, IP) or vehicle was administered and 19 h later, a cocaine dose-locomotor response test was conducted (0, 5, 10, 20 and 40 mg/kg, IP). Chronic cocaine administration augmented the locomotor response to cocaine in chronic cocaine-treated rats, compared to acutely treated controls. Ibogaine pretreatment enhanced the locomotor effects of cocaine in both chronic and acute cocaine groups. Furthermore, due to the shape of the dose-response curve, in chronic cocaine but not in acute cocaine rats, ibogaine pretreatment enhanced the locomotor response to 5 and 10 mg/kg cocaine while decreasing the locomotor response to 40 mg/kg cocaine. These data demonstrate definitively that ibogaine can enhance sensitivity to the locomotor stimulant effects of cocaine, an effect which depends, in part, on the previous cocaine history of the animal.