Psilocybin-induced stimulus control in the rat.
Jerrold C Winter, K C Rice, D J Amorosi, R A Rabin
Pharmacology, Biochemistry, and Behavior October 1, 2007 DOI: 10.1016/j.pbb.2007.06.003 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal model Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | Psilocybin M100907 WAY-100635 remoxipride DOM LSD psilocin DMT 2C-T-7 mescaline MDMA PCP |
| Topics | LSD Psilocybin Serotonin |
| Keywords | Hallucinogens Psychedelics Receptor mechanisms Neuropharmacology Mechanism of action Drug action Molecular mechanisms 5-ht1a receptor Serotonin receptor Antagonist Brain effects Neurobiology Neural pathways Animal models Rats |
| Citations | 73 |
| Key points | Psilocybin's discriminative stimulus in rats involves the 5-HT2A receptor but not the 5-HT1A or dopamine D2 receptors. |
Abstract
Although psilocybin has been trained in the rat as a discriminative stimulus, little is known of the pharmacological receptors essential for stimulus control. In the present investigation rats were trained with psilocybin and tests were then conducted employing a series of other hallucinogens and presumed antagonists. An intermediate degree of antagonism of psilocybin was observed following treatment with the 5-HT(2A) receptor antagonist, M100907. In contrast, no significant antagonism was observed following treatment with the 5-HT(1A/7) receptor antagonist, WAY-100635, or the DA D(2) antagonist, remoxipride. Psilocybin generalized fully to DOM, LSD, psilocin, and, in the presence of WAY-100635, DMT while partial generalization was seen to 2C-T-7 and mescaline. LSD and MDMA partially generalized to psilocybin and these effects were completely blocked by M-100907; no generalization of PCP to psilocybin was seen. The present data suggest that psilocybin induces a compound stimulus in which activity at the 5-HT(2A) receptor plays a prominent but incomplete role. In addition, psilocybin differs from closely related hallucinogens such as 5-MeO-DMT in that agonism at 5-HT(1A) receptors appears to play no role in psilocybin-induced stimulus control.
Comparable studies
Other preclinical and animal studies on psilocybin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo Mice | 2021 | Observational cohort | |
| Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice Mice | 2021 | Experimental study | |
| Psychedelics reopen the social reward learning critical period Mice | 2023 | Experimental study in mice | |
| Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. C57BL/6J mice | 2020 | Experimental study with dose-response experiments | |
| Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning Mice | 2013 | Experimental study |
Citations in the library
Cited by 59
- Psychedelics Promote Structural and Functional Neural Plasticity Cell Reports June 1, 2018
- Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice Proceedings of the National Academy of Sciences April 13, 2021
- The abuse potential of medical psilocybin according to the 8 factors of the Controlled Substances Act Neuropharmacology June 5, 2018
- Potential Therapeutic Effects of Psilocybin. Neurotherapeutics July 1, 2017
- The hallucinogenic world of tryptamines: an updated review. Archives of Toxicology August 1, 2015
and 54 more in the library
Cites 29
- Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance Psychopharmacology July 7, 2006
- Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action Neuroreport December 1, 1998
- Using Psilocybin to Investigate the Relationship between Attention, Working Memory, and the Serotonin 1A and 2A Receptors Journal of Cognitive Neuroscience October 1, 2005
- Psychopathological, neuroendocrine and autonomic effects of 3,4-methylenedioxyethylamphetamine (MDE), psilocybin and d -methamphetamine in healthy volunteers Psychopharmacology February 18, 1999
- Effect of Ring Fluorination on the Pharmacology of Hallucinogenic Tryptamines Journal of Medicinal Chemistry October 19, 2000
and 24 more in the library