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Recurrent seizures and serotonin syndrome following "2C-I" ingestion.

Adam Bosak, Frank Lovecchio, Michael Levine

Journal of Medical Toxicology June 1, 2013 DOI: 10.1007/s13181-013-0287-x (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Case report Peer reviewed
Sample size 1
Population 19-year-old male who insufflated 2C-I
Topics Serotonin
Keywords 2c-i toxicity 2c-i poisoning 2c-i adverse effects 2c-i overdose 2c-i reactions Designer drugs Synthetic drugs Novel psychoactive substances Emerging drugs Medical emergency Acute drug intoxication Drug-induced crisis Critical care Emergency medicine Patient recovery Full recovery Positive patient outcome Clinical recovery
Citations 59
Key findings Insufflation of 2C-I can cause recurrent seizures, serotonin syndrome, and prolonged respiratory failure, with the possibility of full recovery.

Abstract

The phenethylamines, including 2, 5 dimethoxy-4-iodophenethylamine, commonly referred to as 2C-I, have recently emerged as a new class of designer drugs. Cases of toxicity from these drugs are not well described in the literature. This case report describes a 19 year-old male who insufflated 2C-I. Following the ingestion, the patient developed recurrent seizures, and was taken to the emergency department, where he was noted to be hyperadrenergic and had recurrent seizures. The patient was diagnosed with serotonin syndrome and experienced prolonged respiratory failure, although he ultimately made a full recovery. Comprehensive drug testing revealed the presence of 2C-I. The pharmacologic properties of 2C-I are also discussed.

Comparable studies

Other case reports and case series on serotonin, most cited first.

Study Year Design Participants
Lasting Neuropsychiatric Sequelae of (??)Methylenedioxymethamphetamine (???Ecstasy???) in Recreational Users Persons who ingested large doses of MDMA 1991 Case study n = 2
Striatal serotonin is depleted in brain of a human MDMA (Ecstasy) user Chronic MDMA user 2000 Case study n = 1
Death following ingestion of MDMA (ecstasy) and moclobemide People who died after ingesting moclobemide and MDMA 2003 Case series n = 4
Ecstasy Intoxication: An Overlap Between Serotonin Syndrome and Neuroleptic Malignant Syndrome A 19-year-old woman and 15 other cases reported in the literature 1996 Case report and literature review n = 16
Psilocybin and Obsessive Compulsive Disorder Individual with Obsessive Compulsive Disorder 2014 Case study n = 1

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