2C-I-NBOMe, an "N-bomb" that kills with "Smiles". Toxicological and legislative aspects.
Panagiota Nikolaou, Ioannis Papoutsis, Maria Stefanidou, Chara Spiliopoulou, Sotiris Athanaselis
Drug and chemical toxicology 2015 DOI: 10.3109/01480545.2014.911882 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Keywords | 25i-nbome 2c-i-nbome N-bomb Legislation Pharmacology Substituted phenethylamines Toxicology Designer drug Public health Drug intoxication Fatalities Drug policy Global regulation |
| Citations | 62 |
| Key findings | Intoxications and fatal cases related to 2C-I-NBOMe use are increasing worldwide, but the drug is banned only in some countries. |
Abstract
Substituted phenethylamines are a class of designer drugs that have recently emerged in the drug abuse market. Such substances remain legal to use, possess, and supply until these compounds become classified as scheduled. 2C-I-NBOMe or 25I-NBOMe is the N-benzyl-derivative of the iodo-substituted dimethoxy-phenethylamine (2C-I) that appeared recently in the drug market under the street name "N-Bomb". Due to its high potency, intoxications and fatal cases related to 2C-I-NBOMe use are increased worldwide. The use and trafficking of this substituted phenethylamine is banned only in some countries. A comprehensive review was performed using PubMed and Medline databases, together with additional non-peer reviewed information sources, including books and publications of state authorities in different countries, regarding chemistry, availability, pharmacology, and toxicology of 2C-I-NBOMe. Intoxications or lethal cases, published or reported, as well as the current legislation on this newly introduced drug are also reviewed.