Urinary Excretion Profiles of 2,5-Dimethoxy-4-alkylthiophenethylamine Analogs in Rats.
Tatsuyuki Kanamori, Kenji Kuwayama, Kenji Tsujikawa, Yuko T Iwata, Hiroyuki Inoue
Biological & pharmaceutical bulletin 2016 DOI: 10.1248/bpb.b15-00953 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Sample size | 12 |
| Population | Four male Sprague-Dawley rats per drug (total 12 rats) |
| Interventions | 2C-T-2 2C-T-4 2C-T-7 |
| Dose | 10 mg/kg |
| Duration | 48 hours post-administration |
| Keywords | Metabolism Metabolite identification Chemical structure |
| Citations | 1 |
| Key findings | The principal urinary metabolites differed among the three hallucinogenic 2,5-dimethoxy-4-alkylthiophenethylamine analogs in rats. |
Abstract
The urinary metabolic profiles of three hallucinogenic 2,5-dimethoxy-4-alkylthiophenethylamine analogs: 2,5-dimethoxy-4-ethylthiophenethylamine (2C-T-2), 2,5-dimethoxy-4-isopropylthiophenethylamine (2C-T-4), and 2,5-dimethoxy-4-propylthiophenethylamine (2C-T-7), were investigated in rats. For each drug, four male Sprague-Dawley rats were orally administered 10 mg/kg of 2C-T-2, 2C-T-4, or 2C-T-7, and urine was collected 0-24 and 24-48 h after administration. The urine samples were processed by liquid-liquid extraction, and the extracts were analyzed by liquid chromatography/mass spectrometry to quantify the metabolites. The metabolic patterns of these drugs were different: for 2C-T-7, the principal metabolite was the β-hydroxylated-N-acetylated-sulfoxide, whereas for 2C-T-2 and 2C-T-4 the major metabolites were the N-acetylated-sulfoxide and S-methylated-N-acetylated-sulfoxide, respectively.