The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
June 1, 2026
Chittaranjan Behera, Srishti Gupta, Richard C. Shelton et al.
2 citations
Suicide is a major global health problem. Growing evidence shows that immune dysregulation and inflammation contribute to suicidality. This review summarises inflammatory mechanisms associated with suicidal behaviour and evaluates emerging therapeutic strategies targeting these pathways. A narrative literature review was conducted using a combination of keywords, including suicide, therapy,...
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
January 22, 2026
David Eckert, Siegfried Kasper
Treatment-resistant depression (TRD) poses a major challenge in research and clinical practice. Various guidelines recommend different pharmacological approaches. While lithium and second-generation antipsychotics have traditionally been the drugs of choice in cases of medication resistance, recent years have seen increasing evidence for the efficacy of esketamine as a fast-acting agent against...
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
2025
Christine Reif-Leonhard, Shannon N Millard, Dorsa Ferdowssian et al.
3 citations
While neuropsychological effects of conventional antidepressants are well-documented, more research is needed for rapid-acting antidepressants. This study examines the effects of esketamine on emotion processing and cognitive functioning, both acutely and sub-chronically. Eighteen treatment-resistant depression (TRD) patients received repeated intravenous esketamine infusions. Mood state was...
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
November 1, 2024
Samantha Graf, Gregor Dörl, Christian Milz et al.
2 citations
Ketamine exerts rapid antidepressant effects by enhancing neuroplasticity, particularly in the amygdala and hippocampus-regions involved in fear processing and learning. While the role of ketamine's dissociative effects in its antidepressant response is debated, anxiety experienced during infusion has been negatively correlated with treatment outcomes. In this single-blind, placebo-controlled...
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
2009
Robert Paul, Nadine Schaaff, Frank Padberg et al.
Recent studies with intravenous infusion of the NMDA receptor antagonist ketamine showed robust and rapid antidepressant effects within hours after treatment. Ketamine is a racemic mixture consisting of two enantiomers, R- and S-ketamine. In contrast to ketamine, S-ketamine is reported to be less prone to psychomimetic side effects, such as derealisation and hallucinations. In this report we...
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
2009
Carlo Marchesi, Matteo Tonna, Carlo Maggini
We report the case of two young subjects who developed an obsessive-compulsive disorder (OCD) during a heavy use of ecstasy. After several months of discontinuation of the drug, major depression with psychotic features developed in one subject and a psychotic disorder in the other individual. No mental disorder preceded the use of ecstasy in any subject. A familial and personality vulnerability...
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
2009
Francesco Nifosì, Andrea Martinuzzi, Tommaso Toffanin et al.
Acute ingestion of MDMA (ecstasy) causes a transient marked increase in serotonin and dopamine at central synapses. Recent studies demonstrated that MDMA induces damage of serotonergic nerve terminals and alters hippocampal processing. Pronounced cognitive deficits in MDMA users affect learning and memory abilities. This pattern of predominant and long-lasting memory dysfunction suggests that...