Comparison of racemic ketamine and S-ketamine in treatment-resistant major depression: report of two cases.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 2009 Robert Paul, Nadine Schaaff, Frank Padberg et al.
Recent studies with intravenous infusion of the NMDA receptor antagonist ketamine showed robust and rapid antidepressant effects within hours after treatment. Ketamine is a racemic mixture consisting of two enantiomers, R- and S-ketamine. In contrast to ketamine, S-ketamine is reported to be less prone to psychomimetic side effects, such as derealisation and hallucinations. In this report we...