Thinking glutamatergically: changing concepts of schizophrenia based upon changing neurochemical models.
Clinical schizophrenia & related psychoses October 1, 2010 Joshua T Kantrowitz, Daniel C Javitt
Clinical concepts of mental illness have always been modulated by underlying theoretical considerations. For the past fifty years, schizophrenia has been considered primarily a disease of dopaminergic neurotransmission. Although this conceptualization has helped greatly in explaining the clinical effects of psychostimulants and guiding the clinical use of both typical and atypical...