Current Trends in Identifying Rapidly Acting Treatments for Depression.
Current behavioral neuroscience reports June 1, 2016 Dawn F. Ionescu, George I. Papakostas
Traditional antidepressants take weeks to months to work, but ketamine's rapid effects have spurred a decade and a half of research into treatments that act within hours to days, shifting antidepressant drug development. This review highlights recent trends in identifying rapidly-acting antidepressants, discussing ketamine, GLYX-13, nitrous oxide, metabotropic glutamatergic receptor modulators, scopolamine, opioid-receptor modulators, and low field magnetic stimulation.