Inhibition of mirtazapine metabolism by Ecstasy (MDMA) in isolated perfused rat liver model.
Daru June 28, 2017 Sanaz Jamshidfar, Yalda H. Ardakani, Hoda Lavasani et al. 5 citations
Nowadays MDMA (3,4-methylendioxymethamphetamine), known as ecstasy, is widely abused among the youth because of euphoria induction in acute exposure. However, abusers are predisposed to depression in chronic consumption of this illicit compound. Mirtazapine (MRZ), an antidepressant agent, may be prescribed in MDMA-induced depression. MRZ is extensively metabolized in liver by CYP450 isoenzymes....