Psilocybin, a prominent psychedelic, recently emerged as a potential therapeutic agent for psychiatric disorders, yet the molecular and cellular mechanisms driving its effects remain poorly understood. To address these knowledge gaps, we focused on the nucleus accumbens (NAc), a forebrain region that regulates reward, motivation, and emotion. Systemic administration of psilocybin (3 mg/kg)...
This Perspective article outlines a concept of minimal selfhood. A central claim is that minimal selfhood is not dependent on possession of a brain, a nervous system or neurons. It will be argued instead that minimal selfhood requires intrinsically reflexive activity, specifically taking the form of self-maintenance, self-reproduction and self-containment. The implications of this in thinking...