Impact of NEDO Project on Microdosing Clinical Studies: Toward the eIND Study in Japan
Drug Metabolism and Pharmacokinetics 2011 Shinji Yamashita 1 citation
The aim of the present study is to investigate the pharmacokinetics of our newly developed aromatase inhibitors (cetrozole and TMD-322) in healthy subjects by a cassette microdose strategy. A cocktail of cetrozole and TMD-322 was administered intravenously or orally (1.98 μg for each drug) to six healthy volunteers in a crossover fashion. Anastrozole (1.98 μg) was also included in the oral...