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Drug Metabolism and Pharmacokinetics

ISSN 1347-4367

2 papers in the library · 1 citation · publishing 2011-2017

Papers

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Comparison of pharmacokinetics of newly discovered aromatase inhibitors by a cassette microdosing approach in healthy Japanese subjects.

Drug Metabolism and Pharmacokinetics December 2017 Hiroyuki Kusuhara, Tadayuki Takashima, Hisako Fujii et al.

The aim of the present study is to investigate the pharmacokinetics of our newly developed aromatase inhibitors (cetrozole and TMD-322) in healthy subjects by a cassette microdose strategy. A cocktail of cetrozole and TMD-322 was administered intravenously or orally (1.98 μg for each drug) to six healthy volunteers in a crossover fashion. Anastrozole (1.98 μg) was also included in the oral...

DOI: 10.1016/j.dmpk.2017.09.003 (opens in new tab) Full text (opens in new tab) Aromatase inhibitor Cassette dosing approach Lc–ms/ms Microdosing clinical trial +1

Impact of NEDO Project on Microdosing Clinical Studies: Toward the eIND Study in Japan

Drug Metabolism and Pharmacokinetics 2011 Shinji Yamashita 1 citation

The aim of the present study is to investigate the pharmacokinetics of our newly developed aromatase inhibitors (cetrozole and TMD-322) in healthy subjects by a cassette microdose strategy. A cocktail of cetrozole and TMD-322 was administered intravenously or orally (1.98 μg for each drug) to six healthy volunteers in a crossover fashion. Anastrozole (1.98 μg) was also included in the oral...

DOI: 10.2133/dmpk.dmpk-11-pf-906 (opens in new tab)