BACKGROUND: Nightmare complaints are common among individuals with psychiatric disorders and are associated with significant emotional distress and functional impairment. Despite their clinical relevance, they remain frequently under-recognized and under-treated in psychiatric settings. OBJECTIVE: To offer a pragmatic, clinician-oriented framework for the evaluation and management of nightmare...
The hypothesis of monoaminergic deficiency has long dominated the conceptual framework for the development of new antidepressant strategies, but the limits of conventional antidepressant treatments targeting monoaminergic signaling have motivated the search for new antidepressant pathways. The success of ketamine in the management of depressive disorders has provoked a renewed interest in...