Journal of Pain - The Consciousness Library

Feasibility and Tolerability of Psilocybin for Phantom Limb Pain.

Journal of Pain August 1, 2026 Jon G. Dean, Ethan Hurwitz, T. Furnish et al.

Phantom limb pain (PLP) is a refractory condition defined by pain experienced in a missing limb. Psilocybin, a classical serotonergic psychedelic drug, can alleviate various treatment-resistant disorders but has scantly been investigated for chronic pain. This placebo-controlled, double-blind, randomized clinical pilot trial (NCT05224336) tested the feasibility, tolerability, and preliminary...

DOI: 10.1016/j.jpain.2026.106404

Mindfulness-Based Intervention effect on the psychophysiological marker of self-regulation in women with endometriosis-related chronic pain.

Journal of Pain July 1, 2023 Marcelo de França Moreira, O. Gamboa, M. A. Oliveira

Endometriosis is a gynecological disease that involves a broad biopsychosocial compromise with the potential to create a negative vicious cycle. Despite the complexity of factors influencing women's improvement, most interventions investigated target just the peripheral nociceptive sources of endometriosis-related pain. An alternative is intervening in self-regulation, which can potentially...

DOI: 10.1016/j.jpain.2023.07.026

Is Mindfulness Associated With Lower Pain Reactivity and Connectivity of the Default Mode Network? A Replication and Extension Study in Healthy and Episodic Migraine Participants

Journal of Pain August 4, 2022 Carly Hunt, Janelle E. Letzen, Samuel R Krimmel et al. 15 citations

Formal training in mindfulness-based practices promotes reduced experimental and clinical pain, which may be driven by reduced emotional pain reactivity and undergirded by alterations in the default mode network, implicated in mind-wandering and self-referential processing. Recent results published in this journal suggest that mindfulness, defined here as the day-to-day tendency to maintain a...

DOI: 10.1016/j.jpain.2022.07.011 Default mode network Mindfulness Posterior cingulate Chronic pain +9

Moderators of mindfulness meditation, cognitive therapy, and mindfulness-based cognitive therapy for chronic low back pain: A test of the Limit, Activate and Enhance model.

Journal of Pain 2019 Melissa A Day, B. Thorn, Dawn M Ehde et al.

This study examined psychosocial pain treatment moderation in a secondary analysis of a trial that compared cognitive therapy (CT), mindfulness-meditation (MM), and mindfulness-based cognitive therapy (MBCT) for chronic low back pain (CLBP). The Limit, Activate and Enhance (LA&E) model of moderation provided a framework for testing a priori hypotheses. Adult participants (N=69) with CLBP...

DOI: 10.1016/j.jpain.2019.06.006 Full text

Papers

Feasibility and Tolerability of Psilocybin for Phantom Limb Pain.

Mindfulness-Based Intervention effect on the psychophysiological marker of self-regulation in women with endometriosis-related chronic pain.

Is Mindfulness Associated With Lower Pain Reactivity and Connectivity of the Default Mode Network? A Replication and Extension Study in Healthy and Episodic Migraine Participants

Moderators of mindfulness meditation, cognitive therapy, and mindfulness-based cognitive therapy for chronic low back pain: A test of the Limit, Activate and Enhance model.