Pharmacology of Classical Psychedelic in Mouse Models of Chronic Pain
Journal of Pain April 1, 2024 M. Imad Damaj, Eda Koseli, Belle Buzzi et al. 2 citations
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ISSN 1526-5900
4 papers in the library · 3 citations · publishing 2019-2025
Journal of Pain April 1, 2024 M. Imad Damaj, Eda Koseli, Belle Buzzi et al. 2 citations
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Journal of Pain April 1, 2025 Nicholas Gregory, Tyler E. Girard, Akila Ram et al. 1 citation
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Journal of Pain July 1, 2023 Marcelo de França Moreira, O. Gamboa, M. A. Oliveira
A brief Mindfulness-Based Intervention (bMBI) improved attention and autonomic regulation in women with endometriosis-related pain. In a pilot randomized controlled trial, the bMBI group (n=26) showed significantly better accuracy on the Flanker task and faster reaction times on both Flanker and Stroop tasks compared to the control group (n=28). The intervention also increased vagally-mediated heart rate variability at rest and during recovery after cognitive stress. Attention mediated the bMBI's effect on reducing affective pain, but this was linked to reduced parasympathetic tone in the control group, while the mindfulness group improved attention efficiency under higher parasympathetic tone. The authors suggest bMBI may improve self-regulation and provide broad biopsychosocial benefits.
Journal of Pain January 1, 2019 M. Day, B. Thorn, D. Ehde et al.
Different patients with chronic low back pain may benefit from different psychosocial treatments depending on their baseline characteristics. In a secondary analysis of a trial comparing cognitive therapy, mindfulness meditation, and mindfulness-based cognitive therapy for 69 adults, moderation analyses found that baseline pain catastrophizing, brain state (theta power on electroencephalogram), and mindful non-reactivity each predicted which treatment yielded greater improvement in pain intensity, depression, or physical function. For example, higher catastrophizing favored mindfulness meditation for pain intensity, while lower catastrophizing favored mindfulness-based cognitive therapy. The findings support the possibility that patient-treatment matching could optimize outcomes.