Gene

ISSN 1879-0038

2 papers in the library · 3 citations · publishing 2015-2025

Papers

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Esketamine mitigates lung injury in COPD rat models under mechanical ventilation: An RNA-sequencing and bioinformatics analysis of serum exosome miRNA profiles.

Gene August 20, 2025 Ang Liu, Xiao-Hua Gao, Yu Mao et al. 3 citations

This study aims to investigate the protective effects of esketamine on lung injury in rat models of chronic obstructive pulmonary disease (COPD) under mechanical ventilation. The focus is on serum exosome miRNA profiles through RNA sequencing and bioinformatics analysis. Male Sprague-Dawley rats were categorized into four groups: Control (C), COPD model (M), COPD model + saline (MS), and COPD...

DOI: 10.1016/j.gene.2025.149571 Full text Esketamine Copd Exosome Mechanical ventilation +6

Elucidating cannabinoid biology in zebrafish (Danio rerio).

Gene July 17, 2015 Randall G Krug, Karl J Clark

The number of annual cannabinoid users exceeds 100,000,000 globally and an estimated 9% of these individuals will suffer from dependency. Although exogenous cannabinoids, like those contained in marijuana, are known to exert their effects by disrupting the endocannabinoid system, a dearth of knowledge exists about the potential toxicological consequences on public health. Conversely, the...

DOI: 10.1016/j.gene.2015.07.036 Full text Cannabis Marijuana Animals Zebrafish +4