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Journal of Mass Spectrometry

ISSN 1076-5174

2 papers in the library · 171 citations · publishing 2003-2016

Papers

Screening for and validated quantification of amphetamines and of amphetamine‐ and piperazine‐derived designer drugs in human blood plasma by gas chromatography/mass spectrometry

Journal of Mass Spectrometry June 1, 2003 Frank T. Peters, Simone Schaëfer, Roland F. Staack et al. 171 citations

A method was developed to screen for and simultaneously quantify classical stimulants (amphetamine, methamphetamine, ethylamphetamine, MDA, MDMA, MDEA, BDB, MBDB) and newer designer drugs (4-methylthioamphetamine, p-methoxyamphetamine, p-methoxymethamphetamine, and several piperazine derivatives) along with two metabolites in human blood plasma. The technique uses gas chromatography/mass spectrometry with selected-ion monitoring after solid-phase extraction and derivatization. The method was linear from 5 to 1000 µg/L for all analytes, with a limit of quantification of 5 µg/L. Accuracy and precision met required limits except for MDBP. The assay was validated and applicable for confirming immunoassay results positive for amphetamines or ecstasy-type designer drugs.

DOI: 10.1002/jms.483 (opens in new tab) Ecstasy MDMA Designer drug Chemistry +11

Mass spectrometric properties of N‐(2‐methoxybenzyl)‐2‐(2,4,6‐trimethoxyphenyl)ethanamine (2,4,6‐TMPEA‐NBOMe), a new representative of designer drugs of NBOMe series and derivatives thereof

Journal of Mass Spectrometry October 1, 2016 Vadim A Shevyrin, Olga V. Kupriyanova, Albert T. Lebedev et al.

A new compound in the NBOMe series of hallucinogenic phenethylamines, 2,4,6-TMPEA-NBOMe, was identified in the illicit drug market using multiple analytical techniques including GC/MS, high-resolution mass spectrometry, and NMR spectroscopy. The study describes the compound's fragmentation patterns under electron ionization, noting that a McLafferty rearrangement occurs despite an empirical rule that would predict otherwise, and that electron-donating methoxy groups favor this rearrangement. N-methyl and N-acyl derivatives did not show the rearrangement, while N-acyl derivatives exhibited it with charge retention on an alternative fragment. Analytical characteristics for detecting the compound in criminal seizures are provided.

DOI: 10.1002/jms.3808 (opens in new tab)