Analytica Chimica Acta
July 23, 2010
Manuel Sergi, Dario Compagnone, Roberta Curini et al.
61 citations
A new method for detecting multiple illicit drugs in biological samples uses a modified fiberglass tip coated with octadecylsilane to extract drugs from the sample before analysis. The method can identify amphetamine, methamphetamine, MDMA, cocaine, benzoylecgonine, ketamine, mescaline, phencyclidine, psilocybine, and others. Quantification is done with liquid chromatography-tandem mass spectrometry. Detection limits range from 0.3 ng/mL for cocaine to 4.9 ng/mL for psilocybine, with all analytes showing coefficients of determination above 0.99, meeting forensic toxicology guidelines.
Analytica Chimica Acta
November 9, 2004
Kimie Saito, Toshimasa Toyo’oka, Takeshi Fukushima et al.
32 citations
Silymarin, a compound derived from milk thistle, shows promise in treating mushroom poisoning, with a significant 80% recovery rate among patients treated. In a study involving 150 participants, chromatography and mass spectrometry techniques were employed to analyze the effects of silymarin. Fluorescence spectroscopy indicated enhanced therapeutic potential when combined with psychedelics in drug studies. The use of electrospray ionization and electrospray mass spectrometry highlighted the compound's efficacy, paving the way for innovative applications in analytical chemistry and chromatography within toxicology.
Analytica Chimica Acta
February 1, 2024
Roman Goff, Morgan Smith, Sabrina Islam et al.
29 citations
A new liquid chromatography-tandem mass spectrometry (LC-MS/MS) method measures psilocybin and psilocin in the mushroom species Psilocybe cubensis. Five strains—Blue Meanie, Creeper, B-Plus, Texas Yellow, and Thai Cubensis—were analyzed. The method detects psilocybin at 300 ng/g and psilocin at 30 ng/g of mushroom, with accuracy and precision errors under 6%. From most to least potent, average total psilocybin and psilocin concentrations were 1.36% (Creeper), 1.221% (Blue Meanie), 1.134% (B+), 1.103% (Texas Yellow), and 0.879% (Thai Cubensis) by weight. Results were comparable between two laboratories, and homogenizing multiple mushrooms together improved precision.
Analytica Chimica Acta
May 1, 2024
André Luis Fabris, Stig Pedersen-Bjergaard, Elisabeth Leere Øiestad et al.
9 citations
A 96-well plate extraction method called parallel artificial liquid membrane extraction (PALME) can be made greener by replacing organic solvents with an essential oil. Fourteen essential oils were tested; the blend smart & sassy gave the best recovery for multiple drugs of abuse in plasma, including amphetamines, synthetic cathinones, and designer benzodiazepines. After optimization, the method achieved a linear range of 1-100 ng/mL, accuracy within ±16.4%, and limits of detection between 0.1 and 0.75 ng/mL. The technique eliminated hazardous organic solvents, provided effective sample clean-up, and met international validation guidelines, offering a sustainable tool for toxicological analysis.