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March 11, 2026
Jenna Houff, Andrew Williams, Obie Allen et al.
Clinical trials suggest that a single dose of psilocybin may be an effective treatment for substance use disorders. Choice impulsivity is a value-based decision-making bias that predicts drug-intake escalation and is commonly associated with substance use disorders. The dorsomedial prefrontal cortex regulates choice impulsivity and is enriched with 5-HT2A receptors that mediate effects of...
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January 28, 2026
Mark Lemon
This preprint presents a conceptual framework for understanding conscious experience as an aperture-mediated process operating over an invariant geometric structure. The model proposes a twelve-fold toroidal “thoughtform” that admits an equivalent partition into focal lenses, each of which may be described as an archetypal attractor, phase sector, symmetry class, or developmental band depending...
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January 28, 2026
Yunlong Zhang
This paper proposes "Theory of Present-Aspect Monism," a self-consistent philosophical system built from two irrefutable experiential axioms: consciousness and the world only exist in the present. It posits pure consciousness as the sole, non-dual absolute reality, which continuously creates a consistent experiential universe through a "manifestation-observation-remanifestation" cycle. The...
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2026
Jesse Dallery, Jennifer L. Miller, Jeff Boissoneault et al.
Supplementary Material 1
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2026
Jesse Dallery, Jennifer L. Miller, Jeff Boissoneault et al.
Abstract Binge Eating Disorder (BED) is the most prevalent eating disorder and is associated with psychiatric comorbidities, health impairments, and decreased quality of life. Emerging evidence suggests that psilocybin-assisted therapy may promote cognitive and emotional flexibility and disrupt maladaptive behavioral patterns, making it a promising candidate for BED treatment. This open-label...
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2026
Kristian Larsen
This figure shows the acute effects of psilocybin on cerebral blood flow and internal carotid artery diameter in healthy human participants. Whole-brain cerebral blood flow was measured using pseudo-continuous arterial spin labelling MRI at baseline, during the peak and late phases following psilocybin administration (0.2–0.3 mg/kg, N = 28). Cerebral blood flow maps illustrate widespread...
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2026
Kristian Larsen
This figure presents original population-level cerebral blood flow and global functional connectivity responses to LSD and psilocybin in healthy human participants. Peak drug effects are shown for cerebral blood flow and global connectivity, and within-subject associations between these measures are assessed using Spearman’s rank correlation. MRI acquisition, preprocessing, and statistical...
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2026
Jesse Dallery, Jennifer L. Miller, Jeff Boissoneault et al.
Supplementary Material 2
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2026
Daniel Pustay, Vishal Patel, Krista Ulisse et al.
Treatment-resistant depression (TRD) remains a complex challenge, often requiring interventions beyond standard medications. This review explores factors that may predict positive response to electroconvulsive therapy (ECT), repetitive transcranial magnetic stimulation (rTMS) and ketamine-based treatments to help guide clinical decision-making. A systematic review was conducted following PRISMA...
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2026
Kristian Larsen
This figure presents LSD occupancy at the serotonin 2A receptor (5-HT2AR) and global functional connectivity effects in healthy human participants for LSD and psilocybin. PET and fMRI acquisition, preprocessing, and statistical modelling procedures were pre-registered and are described in detail in the study protocol available on medRxiv (https://doi.org/10.1101/2025.06.17.25329677).
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November 26, 2025
The 5-HT2A and 5-HT2C receptors are key therapeutic targets for CNS disorders. We investigated whether a nonhallucinogenic dual 5-HT2A/5-HT2C agonist could offer novel treatment potential. Large screening of in-house structurally diverse compounds revealed centhaquin, an FDA-approved hypovolemic shock drug, as a selective 5-HT2C agonist (EC50: 35 nM). We then synthesized 22 aza-aryl analogs...
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November 10, 2025
Marina D. Luccioni (22593281), Jules T. Wyman (22593284), Edgard O. Espinoza (14827902) et al.
The Sonoran Desert toad (Incilius alvarius) is the only animal known to secrete the psychedelic compound 5-MeO-DMT as a chemical defense, but the source of 5-MeO-DMT in I. alvarius remains unknown. Some amphibians produce chemical defenses endogenously or through symbiotic interactions, while others acquire them from specialized diets. In this study we analyzed toxin gland secretions and diet...
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October 29, 2025
Background Ketamine and esketamine have demonstrated rapid, short-term antidepressant effects in major depressive disorder (MDD), but their relative safety remains unclear. This review aims to update the evidence on the safety of two agents for MDD and indirectly compare their safety and tolerability. Method We systematically searched PubMed, PsycINFO, Embase, and Cochrane databases up to 1 May...
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October 13, 2025
Ibogaine, an indole alkaloid derived from the root bark of Tabernanthe iboga, has long been used in traditional Bwiti healing rituals and shows promise for treating opioid dependence and neurological conditions, but existing psychometric tools fail to capture its distinctive subjective/oneiric (dream-like) effects. To address this gap, we developed the 70-item Ibogaine Experience Scale (IES)...
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October 13, 2025
Francisco González Espejito (22421436), Laura Esteban Rodríguez (16363059), Eduardo J. Pedrero Pérez (22421439) et al.
Adjusted Means, Standard Deviations, and MANCOVA Results for Ibogaine Subjective Experience Scales by Gender.
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October 13, 2025
Theoretical categories of acute subjective effects of ibogaine consumption (retrieved from Kohek and colleagues [13, (p 98)].
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October 13, 2025
Francisco González Espejito (22421436), Laura Esteban Rodríguez (16363059), Eduardo J. Pedrero Pérez (22421439) et al.
Ibogaine, an indole alkaloid derived from the root bark of Tabernanthe iboga, has long been used in traditional Bwiti healing rituals and shows promise for treating opioid dependence and neurological conditions, but existing psychometric tools fail to capture its distinctive subjective/oneiric (dream-like) effects. To address this gap, we developed the 70-item Ibogaine Experience Scale (IES)...
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October 13, 2025
Francisco González Espejito (22421436), Laura Esteban Rodríguez (16363059), Eduardo J. Pedrero Pérez (22421439) et al.
Ibogaine, an indole alkaloid derived from the root bark of Tabernanthe iboga, has long been used in traditional Bwiti healing rituals and shows promise for treating opioid dependence and neurological conditions, but existing psychometric tools fail to capture its distinctive subjective/oneiric (dream-like) effects. To address this gap, we developed the 70-item Ibogaine Experience Scale (IES)...
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August 20, 2025
Danielle S. Stolzenberg
Data files associated with the manuscript titled: Psilocybin during the postpartum period induces long-lasting adverse effects in both mothers and offspring. These files contain the analyses used for each figure of the paper including the supplement. The postpartum stress protocol is included along with all of the raw maternal behavior data. Additional raw data can be found in the manuscript...
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2025
Daniel J. Kruger, Gina Mersereau, Ashley Sullivan et al.
Abstract Background The use of psychedelics is currently increasing in the United States. Awareness of clinical trials investigating the therapeutic applications of psychedelics may result in a record number of people who use psychedelics for the first-time. This study aimed to develop a harm-reduction resource to facilitate safe and successful psychedelic experiences outside of regulated...
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2022
Lily Ainsworth
Ayahuasca tourism in Peru has been widely examined, but few accounts consider all factors leading to a sense of transformation, or discuss the integration phase. This phenomenon has been conceputalised as drug, medical, and spiritual tourism, but considering the underlying desire to transform, this thesis will suggest a new label: tourism for transformation. Through ethnographic fieldwork at an...
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2021
Samuel J. Hogarth
Submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Psychology and Public Health, College of Science, Health and Engineering, La Trobe University, Victoria.
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2021
Piotr Popik, Adam S. Hogendorf, Ryszard Bugno et al.
Dataset for the paper: Effects of ketamine optical isomers, psilocybin, psilocin and norpsilocin on time estimation and cognition in rats
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2021
Jeremy Weleff, Teddy J. Akiki, Brian S. Barnett
Dataset for a bibliometric analysis of journal articles reporting findings from clinical studies of the psychedelics 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT), ayahuasca, dimethyltryptamine (DMT), ibogaine, lysergic acid diethylamide (LSD), mescaline, MDMA, and psilocybin published from 1965-2018.This data accompanies our article:Bibliometric Analysis of Academic Journal Articles Reporting...
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2020
Brian S. Barnett, Yvan Beaussant, Franklin King et al.
3 citations
A survey instrument used to gauge knowledge and opinions of psychiatrists attending national professional conferences about psychedelics and psychedelic assisted psychotherapies.