The Action on Psilocybin in Neural Plasticity, Brain Reorganization and Cognitive Enhancement
Middle East Research Journal of Biological Sciences September 28, 2024 Carlos Henrique Marchiori, Marco Vinícios de Oliveira Santana, Klebert de Paula Malheiros
Psilocybin and psilocin do not cause addiction or dependence because they do not interact with the dopaminergic reward system. This narrative review examines psilocybin's action on neural plasticity, brain reorganization, and cognitive enhancement. Psilocybin is an indole alkaloid of the hallucinogenic tryptamine group, structurally similar to serotonin. In Brazil, it is authorized by Anvisa through Ordinance 344 of 1998 with special authorization. The review suggests psilocybin may improve conditions such as depression, anxiety, and cognition, and help with withdrawal symptoms from addiction, with increased concentration and improved brain activity.