ISSN 2374-7943
5 papers in the library · 40 citations · publishing 2017-2025
ACS Central Science July 3, 2025 Mara Johnson-Groh 3 citations
Some scientists think that including secondary compounds from psychedelic mushrooms can make for better drugs. With scarce data, others remain skeptical.
ACS Central Science February 14, 2024 Ryan A Shenvi 37 citations
Research into natural products emerged from humanity's curiosity about the nature of matter and its role in the materia medica of diverse civilizations. Plants and fungi, in particular, supplied materials that altered behavior, perception, and well-being profoundly. Many active principles remain well-known today: strychnine, morphine, psilocybin, ephedrine. The potential to circumvent the...
ACS Central Science August 23, 2023 Sarah J Hill, Nathan Dao, Vuong Q. Dang et al.
The salvinorins serve as templates for next generation analgesics, antipruritics, and dissociative hallucinogens via selective and potent agonism of the kappa-opioid receptor (KOR). In contrast to most opioids, the salvinorins lack basic amines and bind with high affinity and selectivity via complex polyoxygenated scaffolds that have frustrated deep-seated modification by synthesis. Here we...
ACS Central Science August 10, 2023 Bhawyanth Duvvuru, Myles W. Smith
Natural products have served as rich sources of therapeutics dating back to the earliest human civilizations in the form of traditional medicines and more recently as single molecule therapies for a range of diseases. Their diverse biological activities stem from their often complex structures, which can endow natural products with desirable properties relative to synthetic molecules found in...
ACS Central Science December 27, 2017 Jeremy J Roach, Yusuke Sasano, Cullen L. Schmid et al.
Salvinorin A (SalA) is a plant metabolite that agonizes the human kappa-opioid receptor (κ-OR) with high affinity and high selectivity over mu- and delta-opioid receptors. Its therapeutic potential has stimulated extensive semisynthetic studies and total synthesis campaigns. However, structural modification of SalA has been complicated by its instability, and efficient total synthesis has been...