An evaluation of the irrational use of smoking mixtures containing entheogens, specifically the Amanita muscaria mushroom, was conducted through multidisciplinary pharmacognostic, forensic, pharmaceutical, clinical, toxicological, and legal analyses. The study concluded that such use is irrational. A forensic medical and toxicological examination of Amanita poisoning was performed, and pharmaceutical safety measures for poisoning cases were informed. A pharmacognostic study of Amanita muscaria was conducted. Based on normative analysis of the circulation of fly agaric entheogens, regulatory initiatives were proposed. The mushroom contains psychoactive substances psilocybin or psilocin with hallucinogenic effects.
Salvia divinorum and its active compound Salvinorin A pose high toxicological risk, rapid psychotropic action, and legal control difficulties. Their availability online and in informal markets, combined with a perception as natural products, challenges public health, forensic practice, and regulators. The rapid onset of effects, unpredictable behavioral reactions, and difficulty detecting use via routine toxicology increase their relevance for medico-pharmaceutical law and forensic pharmacy. Italy's experience and the new EUDA mandate show that effective counteraction requires legislative control, forensic pharmaceuticals, digital market monitoring, prevention, early-warning systems, public education, and health system preparedness. Cross-border distribution, internet promotion, and misleading marketing as harmless herbal products need attention. An integrated approach can reduce misuse, improve detection, and strengthen cooperation among healthcare, law enforcement, forensic experts, and regulators.