Journal of Chromatography B - The Consciousness Library

Detection of mescaline in human hair samples by UPLC-MS/MS: Application to 19 authentic forensic cases

Journal of Chromatography B March 2, 2022 Shuo Yang, Yan Shi, Zhuonan Chen et al. 13 citations

Mescaline, a natural alkaloid found in the peyote cactus (Lophophora williamsii) in the Americas, has gradually become a drug of abuse in China because of its psychedelic properties. Its intake may lead to hallucinations and confusion or even be life-threatening. Mescaline is classified as a class Ⅰ psychotropic drug in China, which means its use in medicine or scientific research is under...

DOI: 10.1016/j.jchromb.2022.123202 Mescaline Detection limit Gas chromatography–mass spectrometry Forensic toxicology +1

Development and validation of an LC-MS/MS method for the bioanalysis of psilocybin’s main metabolites, psilocin and 4-hydroxyindole-3-acetic acid, in human plasma

Journal of Chromatography B December 7, 2020 Karolina E. Kolaczynska, Matthias E. Liechti, Urs Duthaler 55 citations

Psilocin is the active metabolite of psilocybin, a serotonergic psychedelic substance. It is used recreationally and investigated in substance-assisted psychotherapy. The pharmacokinetic properties of psilocin are only partially characterized. Therefore, we developed and validated a rapid LC-MS/MS method to quantify psilocin and its metabolite 4-hydroxyindole-3-acetic acid (4-HIAA) in human...

DOI: 10.1016/j.jchromb.2020.122486 Psilocybin Chromatography Protein precipitation Metabolite +9

Validation of an analytical method for the determination of the main ayahuasca active compounds and application to real ayahuasca samples from Brazil

Journal of Chromatography B June 8, 2019 Rita C. Z. Souza, Flávia Da Silva Zandonadi, Donizete P. Freitas et al. 42 citations

Ayahuasca is a brew prepared from the water decoction of two Amazonian plants, which is legally used for religious, cultural or therapeutic activities. The potential use of ayahuasca as a natural or phytotherapeutic drug is directly linked to the action of its active compounds and their connection with the therapeutic efficacy of the beverage. In this context, the aim of the present study was...

DOI: 10.1016/j.jchromb.2019.06.014 Ayahuasca Harmine Context archaeology Harmaline +6

Determination of N,N-dimethyltryptamine in Mimosa tenuiflora inner barks by matrix solid-phase dispersion procedure and GC–MS

Journal of Chromatography B November 17, 2011 Alain Gaujac, Adriano Aquino, Sandro Navickiene et al. 30 citations

N,N-dimethyltryptamine (DMT) is a potent hallucinogen found in beverages consumed in religion rituals and neo-shamanic practices over the world. Two of these religions, Santo Daime and União do Vegetal (UDV), are represented in countries including Australia, the United States and several European nations. In some of this countries there have been legal disputes concerning the legalization of...

DOI: 10.1016/j.jchromb.2011.11.014 Ayahuasca Detection limit Chromatography Matrix chemical analysis +3

Liquid chromatography–tandem mass spectrometry determination of LSD, ISO-LSD, and the main metabolite 2-oxo-3-hydroxy-LSD in forensic samples and application in a forensic case

Journal of Chromatography B January 29, 2005 Sys Stybe Johansen, Jytte Lundsby Jensen 41 citations

A liquid chromatography mass spectrometric (LC/MS/MS) method has been developed for the determination of LSD, iso-LSD and the metabolite 2-oxo-3-hydroxy-LSD in forensic applications. The procedure involves liquid-liquid extraction of the analytes and LSD-D3 (internal standard) from 1.0 g whole blood or 1.0 ml urine with butyl acetate at pH 9.8. Confirmation and quantification were done by...

DOI: 10.1016/j.jchromb.2004.12.040 Analyte Detection limit Liquid chromatography–mass spectrometry Forensic toxicology +4

Optimized glucuronide hydrolysis for the detection of psilocin in human urine samples

Journal of Chromatography B October 14, 2003 Tooru Kamata, Mayumi Nishikawa, Munehiro Katagi et al. 65 citations

In order to develop a sensitive and reliable analytical method for psilocin (PC) in urine samples, the hydrolysis conditions including the acid, alkaline and enzymatic hydrolyses have been investigated by monitoring not only PC but also psilocin glucuronide (PCG) by liquid chromatography tandem mass spectrometry (LC-MS-MS); PCG was initially identified in a "magic mushroom (MM)" user's urine by...

DOI: 10.1016/j.jchromb.2003.08.030 Enzymatic hydrolysis Glucuronide Alkaline hydrolysis Urine +3

Determination of N,N-dimethyltryptamine and β-carboline alkaloids in human plasma following oral administration of Ayahuasca

Journal of Chromatography B October 11, 2002 Mercedes Yritia, Jordi Riba, Jordi Ortuño et al. 84 citations

Ayahuasca is a South American psychotropic beverage prepared from plants native to the Amazon River Basin. It combines the hallucinogenic agent and 5-HT(2A/2C) agonist N,N-dimethyltryptamine (DMT) with beta-carboline alkaloids showing monoamine oxidase-inhibiting properties. In the present paper, an analytical methodology for the plasma quantification of the four main alkaloids present in...

DOI: 10.1016/s1570-0232(02)00397-5 Ayahuasca Harmaline Harmine Alkaloid +7

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