SynthesisAugust 31, 2026Zackary D Firestone, Ryan C Harbit, Joel M Smith
Several of the most efficient syntheses of the ergoline lysergic acid hinge on a Heck annulation strategy for the construction of the target's central ring. When bearing an ester functionality at C8, results from various research groups have indicated that the stereochemistry of the ester may be important to the overall mechanism of the cyclization. In this report, we aim to deconvolute the...
Described herein is an improved synthesis of 3-[2-(dimethylamino)ethyl]-1H-indol-4-yl dihydrogen phosphate (psilocybin). The protocol outlines: synthesis of multigram quantities of psilocybin, identification of critical in-process parameters, and isolation of psilocybin without the use of chromatography, TLC, or aqueous workup. The synthesis furnishes psilocybin in five steps in 23% overall...
SynthesisAugust 20, 2018I. Dimitrov, W. Denny, Jiney Jose
Abstract Ketamine [2-(2-chlorophenyl)-2-(methylamino)cyclohexanone] is a dissociative anaesthetic, first developed in 1963 by Parke-Davis. It finds widespread application in the treatment of battlefield injuries, and in emergency departments for use in children. In recent times the clinical interest in ketamine has increased due to the positive impact it has in treating depression and the rapid...
An improved procedure to accomplish the O-phosphor- ylation of 4-hydroxy-N,N-dimethyltryptamine (psilocin 5) is report- ed that utilizes reaction between the O-lithium salt of 5 and tetra-O- benzylpyrophosphate. The O-benzyl groups were removed by cata- lytic hydrogenation over palladium on carbon to afford N,N-dime- thyl-4-phosphoryloxytryptamine (psilocybin, 1). In view of difficulties...